Evidence map›Paper›PMID 35409212›Full record

ArticleInternational journal of molecular sciences2022

Sensing the Messenger: Potential Roles of Cyclic-di-GMP in Rickettsial Pathogenesis.

Hema P Narra, Abha Sahni, Krishna Mohan Sepuru, Jessica Alsing, Sanjeev K Sahni

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Hema P NarraDepartment of Pathology, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA.
Abha SahniDepartment of Pathology, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA.
Krishna Mohan SepuruDepartment of Molecular Biosciences, Howard Hughes Medical Institute, The University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0002-3675-6294
Jessica AlsingDepartment of Pathology, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA.
Sanjeev K SahniDepartment of Pathology, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA.
The University of Texas Medical Branch at Galveston · USHoward Hughes Medical Institute · US

Funding

Novel Bacterial Small RNAs as Determinants of Rickettsial Virulence and TransmissionR01AI127899 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI NARRA, HEMA PRASAD · 2018 to 2021
$2.1M
Institute for Human Infections and Immunity, UTMB Instititional fundsNational Institute of Allergy and Infectious Diseases 5R01 AI127899-04NIAID NIH HHS R01 AI127899
6 · The paper itself

Abstract

Pathogenic bacteria causing human rickettsioses, transmitted in nature by arthropod vectors, primarily infect vascular endothelial cells lining the blood vessels, resulting in 'endothelial activation' and onset of innate immune responses. Nucleotide second messengers are long presumed to be the stimulators of type I interferons, of which bacterial cyclic-di-GMP (c-di-GMP) has been implicated in multiple signaling pathways governing communication with other bacteria and host cells, yet its importance in the context of rickettsial interactions with the host has not been investigated. Here, we report that all rickettsial genomes encode a putative diguanylate cyclase

Indexed as

Endothelial CellsRickettsiaBacterial ProteinsCyclic GMPGene Expression Regulation, BacterialHumansRickettsia rickettsiiVirulenceBacterial Proteinsbis(3',5')-cyclic diguanylic acidCyclic GMPcyclic di-GMPhost-pathogen interactionresponse regulator PleDRickettsiavirulence

Identifiers

PMID35409212
PMCPMC8999164
OpenAlexW4221100209

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.