Evidence map›Paper›PMID 35409202›Full record

ArticleInternational journal of molecular sciences2022

Fecal Microbiota Transplant in a Pre-Clinical Model of Type 2 Diabetes Mellitus, Obesity and Diabetic Kidney Disease.

Rosana M C Bastos, Antônio Simplício-Filho, Christian Sávio-Silva, Luiz Felipe V Oliveira, Giuliano N F Cruz, Eliza H Sousa, Irene L Noronha, Cristóvão L P Mangueira, Heloísa Quaglierini-Ribeiro, Gleice R Josefi-Rocha and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 4 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 4 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Nutrients · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Rosana M C BastosHospital Israelita Albert Einstein, São Paulo 05652-900, SP, Brazil.
Antônio Simplício-FilhoHospital Israelita Albert Einstein, São Paulo 05652-900, SP, Brazil.
Christian Sávio-SilvaHospital Israelita Albert Einstein, São Paulo 05652-900, SP, Brazil.
Luiz Felipe V OliveiraBiomeHub, Santa Catarina 88040-900, SC, Brazil.ORCID 0000-0003-4535-0621
Giuliano N F CruzBiomeHub, Santa Catarina 88040-900, SC, Brazil.
Eliza H SousaHospital Israelita Albert Einstein, São Paulo 05652-900, SP, Brazil.
Irene L NoronhaDivision of Nephrology, School of Medicine, University of São Paulo, São Paulo 01246-903, SP, Brazil.
Cristóvão L P MangueiraHospital Israelita Albert Einstein, São Paulo 05652-900, SP, Brazil.
Heloísa Quaglierini-RibeiroHospital Israelita Albert Einstein, São Paulo 05652-900, SP, Brazil.
Gleice R Josefi-RochaHospital Israelita Albert Einstein, São Paulo 05652-900, SP, Brazil.ORCID 0000-0002-3319-760X
Érika B RangelHospital Israelita Albert Einstein, São Paulo 05652-900, SP, Brazil.
Hospital Israelita Albert Einstein · BRUniversidade de São Paulo · BR

Funding

European Foundation for the Study of Diabetes/Sanofi 2015National Council for Scientific and Technological Development 2016-5/423320São Paulo Research Foundation 2013/19560-6; 2017/23195-2; 2017/18072-9; 2016/26263-6
6 · The paper itself

Abstract

Diabetes mellitus (DM) burden encompasses diabetic kidney disease (DKD), the leading cause of end-stage renal disease worldwide. Despite compelling evidence indicating that pharmacological intervention curtails DKD progression, the search for non-pharmacological strategies can identify novel targets for drug development against metabolic diseases. One of those emergent strategies comprises the modulation of the intestinal microbiota through fecal transplant from healthy donors. This study sought to investigate the benefits of fecal microbiota transplant (FMT) on functional and morphological parameters in a preclinical model of type 2 DM, obesity, and DKD using BTBR

Indexed as

Diabetes Mellitus, Type 2Diabetic NephropathiesAlbuminuriaAnimalsFecal Microbiota TransplantationMiceMice, Inbred StrainsObesitydiabetes mellitusdiabetic kidney diseasefecal transplantgut microbiotaobesity

Identifiers

PMID35409202
PMCPMC8998923
OpenAlexW4220693445

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.