Evidence map›Paper›PMID 35409185›Full record

ArticleInternational journal of molecular sciences2022

BECLIN1 Is Essential for Podocyte Secretory Pathways Mediating VEGF Secretion and Podocyte-Endothelial Crosstalk.

Tillmann Bork, Wei Liang, Oliver Kretz, Simon Lagies, Kosuke Yamahara, Camila Hernando-Erhard, Martin Helmstädter, Christoph Schell, Bernd Kammerer, Tobias B Huber

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The Life of a Kidney Podocyte.Acta physiologica (Oxford, England) · 2025
    Review
  5. Review
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Tillmann BorkDepartment of Medicine IV, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Wei LiangDivision of Nephrology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Oliver KretzIII Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Simon LagiesCentre for Integrative Signalling Analysis, University of Freiburg, 79104 Freiburg, Germany.ORCID 0000-0002-5245-1781
Kosuke YamaharaDepartment of Medicine, Shiga University of Medical Science, Otsu 520-2192, Japan.
Camila Hernando-ErhardDepartment of Medicine IV, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Martin HelmstädterDepartment of Medicine IV, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.ORCID 0000-0001-6027-0094
Christoph SchellInstitute of Surgical Pathology, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Bernd KammererCentre for Integrative Signalling Analysis, University of Freiburg, 79104 Freiburg, Germany.ORCID 0000-0002-4631-8853
Tobias B HuberIII Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
University of Freiburg · DEUniversität Hamburg · DEShiga University of Medical Science · JPWuhan University · CN

Funding

European Research Council 616891
6 · The paper itself

Abstract

Vascular endothelial growth factor A (VEGFA) secretion from podocytes is crucial for maintaining endothelial integrity within the glomerular filtration barrier. However, until now, the molecular mechanisms underlying podocyte secretory function remained unclear. Through podocyte-specific deletion of BECLIN1 (

Indexed as

PodocytesAnimalsBeclin-1Glomerular Filtration BarrierMiceSecretory PathwayVascular Endothelial Growth Factor ABeclin-1Vascular Endothelial Growth Factor AautophagyBECLIN1glomerulosclerosisGolgi networkpodocytesecretory pathwayVEGF

Identifiers

PMID35409185
PMCPMC8998849
OpenAlexW4221137108

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.