Evidence map›Paper›PMID 35409070›Full record

ReviewInternational journal of molecular sciences2022

Host and Viral Zinc-Finger Proteins in COVID-19.

Sabrina Esposito, Gianluca D'Abrosca, Anna Antolak, Paolo Vincenzo Pedone, Carla Isernia, Gaetano Malgieri

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Observational
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Small molecules in the treatment of COVID-19.Signal transduction and targeted therapy · 2022
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sabrina EspositoDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, Università della Campania, Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy.ORCID 0000-0001-6750-7365
Gianluca D'AbroscaDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, Università della Campania, Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy.ORCID 0000-0002-1786-4249
Anna AntolakDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, Università della Campania, Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy.ORCID 0000-0002-8008-8684
Paolo Vincenzo PedoneDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, Università della Campania, Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy.
Carla IserniaDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, Università della Campania, Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy.ORCID 0000-0002-1504-2479
Gaetano MalgieriDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, Università della Campania, Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy.ORCID 0000-0002-4070-9458

Funding

University of Campania "Luigi Vanvitelli" V:ALERE (VAnviteLli pEr la RicErca) program
6 · The paper itself

Abstract

An unprecedented effort to tackle the ongoing COVID-19 pandemic has characterized the activity of the global scientific community over the last two years. Hundreds of published studies have focused on the comprehension of the immune response to the virus and on the definition of the functional role of SARS-CoV-2 proteins. Proteins containing zinc fingers, both belonging to SARS-CoV-2 or to the host, play critical roles in COVID-19 participating in antiviral defenses and regulation of viral life cycle. Differentially expressed zinc finger proteins and their distinct activities could thus be important in determining the severity of the disease and represent important targets for drug development. Therefore, we here review the mechanisms of action of host and viral zinc finger proteins in COVID-19 as a contribution to the comprehension of the disease and also highlight strategies for therapeutic developments.

Indexed as

COVID-19Antiviral AgentsHumansPandemicsSARS-CoV-2ZincAntiviral AgentsZinccoronavirusCOVID-19SARS-CoV-2therapyzinc finger

Identifiers

PMID35409070
PMCPMC8998646

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.