ArticleInternational journal of molecular sciences2022
Circulating Vitreous microRNA as Possible Biomarker in High Myopic Eyes with Macular Hole.
Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Systematic review on biomarker potential of vitreous microRNA in retinal disease.Frontiers in ophthalmology · 2025Pooled it
- The mClinical epigenetics · 2026Article
- Associations between Ocular Surface Microbiome and Refractive Status in Children and Adolescents.Ophthalmology science · 2026Article
- Covariation of scleral remodeling and PI3K/Akt signaling pathway in experimental myopia.Scientific reports · 2025Article
- Associations between per- and polyfluoroalkyl substance exposure and the prevalence of myopia in adolescents: the mediating role of serum albumin.Environmental health and preventive medicine · 2025Article
- The role of inflammation in myopic retinopathy.Frontiers in ophthalmology · 2025Review
- Research Progress of Epigenetic Modifications in Myopia.International journal of medical sciences · 2025Review
- Biomarkers: Promising Tools Towards the Diagnosis, Prognosis, and Treatment of Myopia.Journal of clinical medicine · 2024Review
- Unmasking of molecular players: proteomic profiling of vitreous humor in pathologic myopia.BMC ophthalmology · 2024Observational
- Molecular changes in intraocular fluid: implications for myopia.International journal of biological sciences · 2024Review
- MicroRNA-152-3p and MicroRNA-196a-5p Are Downregulated When Müller Cells Are Promoted by Components of the Internal Limiting Membrane: Implications for Macular Hole Healing.International journal of molecular sciences · 2023Article
- Exosomal MicroRNA Profiling in Vitreous Humor Derived From Pathological Myopia Patients.Investigative ophthalmology & visual science · 2023Article
- Effects of inflammation on myopia: evidence and potential mechanisms.Frontiers in immunology · 2023Review
- Difference in aqueous concentration and vitreous mass of cytokines in high myopias with and without choroidal neovascularization.Frontiers in medicine · 2022Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
High myopia is a major cause of irreversible visual impairment globally. In the present study, we investigated the microRNA (miRNA) profile in the vitreous of macular hole (MH) and high myopic MH. We performed miRNA analysis using TaqMan® Low Density Arrays (Thermo Fisher Scientific, Waltham, MA, USA) to investigate the circulating vitreous miRNA profile from patients with MH (axial length < 26.5 mm, n = 11) and high myopic MH (axial length ≥ 26.5 mm, n = 11) who underwent pars plana vitrectomy. The vitreous inflammatory cytokine signature was examined in high myopic MH eyes using a multiplex assay. A miRNA-Array analysis revealed that let-7c was significantly up-regulated and miR-200a was significantly down-regulated in high myopic MH eyes compared to those in MH eyes. The bioinformatics analysis for up-regulated miRNA targeted gene identified 23 pathways including mitogen-activated protein kinase (MAPK) and several inflammatory signaling pathways, whereas the bioinformatics analysis for down-regulated miRNA targeted genes showed 32 enriched pathways including phosphoinositide 3-kinase/protein kinase B (PI3K/AKT). The levels of inflammatory cytokines including IP-10, IFN-γ, and MCP-1 were significantly higher in the vitreous of high myopic MH eyes. These results suggest that specific miRNAs expressed in the vitreous may be associated with the pathological condition of high myopic MH and the above mentioned miRNAs may contribute to the development of inflammatory status in the vitreous of high myopic eyes.
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