Evidence map›Paper›PMID 35408994›Full record

ReviewInternational journal of molecular sciences2022

Neutrophil to Lymphocyte Ratio: An Emerging Marker of the Relationships between the Immune System and Diseases.

Agata Buonacera, Benedetta Stancanelli, Michele Colaci, Lorenzo Malatino

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 639 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
639citing papers in PubMed, 6 pooled it
85.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

639 citing papers in PubMed, 6 syntheses or guidelines pooled it, 891 citations in OpenAlex.

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579 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Agata BuonaceraEmergency Department, Policlinico S. Marco, 95121 Catania, Italy.
Benedetta StancanelliUnit of Internal Medicine, Policlinico S. Marco, 95121 Catania, Italy.
Michele ColaciAcademic Unit of Internal Medicine and Hypertension Centre, Department of Clinical and Experimental Medicine, University of Catania, Cannizzaro Hospital, 95126 Catania, Italy.ORCID 0000-0002-3606-3404
Lorenzo MalatinoAcademic Unit of Internal Medicine and Hypertension Centre, Department of Clinical and Experimental Medicine, University of Catania, Cannizzaro Hospital, 95126 Catania, Italy.ORCID 0000-0003-2944-2729
Policlinico Universitario di Catania · ITUniversity of Catania · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the last 10 years, the evaluation of the neutrophil-to-lymphocyte ratio (NLR) as an emerging marker of diseases has become a compelling field of bio-medical research. Although a precise and unique cut-off value has not been yet found, its role as a flag of immune system homeostasis is well established. NLR has a well-known prognostic value and independently correlates with mortality in the general population and in several specific subsets of disease (sepsis, pneumonia, COVID-19, cancer, etc.). Moreover, NLR was recently considered as part of the decision-making processes concerning the admission/recovery of patients with COVID-19 pneumonia. This review aims to provide an overview of the main use of this biomarker, focusing on the pathophysiology and the molecular basis underlying its central role as a reliable mirror of inflammatory status and adaptive immunity.

Indexed as

COVID-19NeutrophilsBiomarkersHumansLymphocyte CountLymphocytesRetrospective StudiesBiomarkerscoronavirus disease-2019 (COVID-19)intensive care unit (ICU)markermortalityneutrophil-to-lymphocyte ratio (NLR)prognosissepsis

Identifiers

PMID35408994
PMCPMC8998851
OpenAlexW4220706225

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.