ReviewInternational journal of molecular sciences2022
Industrially Relevant Enzyme Cascades for Drug Synthesis and Their Ecological Assessment.
Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Proximity-enhanced co-immobilized enzyme cascade for efficient bioconversion of nicotine to 3-succinoylpyridine.Bioresources and bioprocessing · 2026Article
- Characterization of RmlABCD Enzymes from Marine Bacteria and Efficient Synthesis of dTDP-L-Rhamnose.Microorganisms · 2026Article
- Nature-Inspired Enzymatic Cascades: Emerging Strategies for Sustainable Chemistry.Molecules (Basel, Switzerland) · 2026Review
- Engineered strains as living factories: efficient biosynthesis and modification of natural products via synthetic biology and one-pot chemical tandem reactions.Frontiers in microbiology · 2026Review
- Optimized Machine Learning for Autonomous Enzymatic Reaction Intensification in a Self-Driving Lab.Biotechnology and bioengineering · 2025Article
- Three-Step One-Pot Photocatalytic Oxidation of Feedstocks and Organocatalytic Sequential Cascade to Access Enantioenriched α-Aminonitriles.ChemSusChem · 2025Article
- A structure-oriented kinetics dataset of enzyme-substrate interactions.Scientific data · 2025Article
- Cascade enzymatic synthesis of a statin side chain precursor - the role of reaction engineering in process optimization.RSC advances · 2024Article
- Recent Developments and Applications of Biocatalytic and Chemoenzymatic Synthesis for the Generation of Diverse Classes of Drugs.Current pharmaceutical biotechnology · 2024Article
- Contribution of Enzyme Catalysis to the Achievement of the United Nations' Sustainable Development Goals.Molecules (Basel, Switzerland) · 2023Article
- Biocatalysis: An Eco-Friendly Scenario for the Manufacturing of APIs.International journal of molecular sciences · 2023Article
- Biological activity of new bioactive steroids deriving from biotransformation of cortisone.Microbial cell factories · 2022Article
- Microbial Lipases and Their Potential in the Production of Pharmaceutical Building Blocks.International journal of molecular sciences · 2022Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Environmentally friendly and sustainable processes for the production of active pharmaceutical ingredients (APIs) gain increasing attention. Biocatalytic synthesis routes with enzyme cascades support many stated green production principles, for example, the reduced need for solvents or the biodegradability of enzymes. Multi-enzyme reactions have even more advantages such as the shift of the equilibrium towards the product side, no intermediate isolation, and the synthesis of complex molecules in one reaction pot. Despite the intriguing benefits, only a few enzyme cascades have been applied in the pharmaceutical industry so far. However, several new enzyme cascades are currently being developed in research that could be of great importance to the pharmaceutical industry. Here, we present multi-enzymatic reactions for API synthesis that are close to an industrial application. Their performances are comparable or exceed their chemical counterparts. A few enzyme cascades that are still in development are also introduced in this review. Economic and ecological considerations are made for some example cascades to assess their environmental friendliness and applicability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.