ReviewInternational journal of molecular sciences2022
The Molecular Basis and Pathophysiology of Trigeminal Neuralgia.
Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 4 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- The efficacy of surgical interventions for trigeminal neuralgia in multiple sclerosis: A systematic review.Neurosurgical review · 2026Pooled it
- Efficacy and safety of different acupuncture-related therapies for primary trigeminal neuralgia: a systematic review and network meta-analysis.Frontiers in pain research (Lausanne, Switzerland) · 2026Pooled it
- Outcomes of trigeminal nerve microsurgical internal neurolysis for trigeminal neuralgia without neurovascular conflict: a systematic review and meta-analysis.Neurosurgical review · 2025Pooled it
- Comparison of stereotactic radiosurgery and rhizotomy for trigeminal neuralgia: A systematic review and Meta-Analysis.Neurosurgical review · 2025Pooled it
- Comparison of Gasserian ganglion conventional radiofrequency ablation and peripheral nerve pulsed radiofrequency in trigeminal neuralgia: a retrospective cohort study.Journal of oral & facial pain and headache · 2026Trial
- Neural Mechanisms and Brain Alterations in Orofacial Pain: A Narrative Review of Human Neuroimaging.Diagnostics (Basel, Switzerland) · 2026Review
- Clinical Characteristics and Early Pain Outcomes After Microvascular Decompression for Trigeminal Neuralgia: A Single-Center Retrospective Cohort Study.Brain sciences · 2026Article
- Treatment of Typical and Atypical Trigeminal Neuralgia with LINAC-Based Radiosurgery: Complications, Recurrence Rates and Long-Term Treatment Outcomes.Journal of clinical medicine · 2026Article
- Does Acupuncture Produce Durable Analgesia in Trigeminal Neuralgia? An Updated Systematic Review and Meta-Analysis.Healthcare (Basel, Switzerland) · 2026Review
- Transcriptional correlates of structure-function coupling plasticity in trigeminal neuralgia: unveiling the synaptic and metabolic associations.The journal of headache and pain · 2026Article
- A modified FLIT-B model of trigeminal neuralgia reveals anterior cingulate cortex involvement in anxiety-like behavior in mice.The journal of headache and pain · 2026Article
- Review
- Impact of climatic factors on trigeminal neuralgia and facial neuropathy in primary care during a fourteen-year time-series study.Scientific reports · 2026Article
- Secondary trigeminal neuralgia: an in-depth review of etiopathology, clinical manifestations, and management approaches.International journal of surgery open · 2026Review
- Partial sensory rhizotomy in therapy-refractory and recurrent trigeminal neuralgia - a single center experience.Acta neurochirurgica · 2026Article
- Clinical outcomes of linear accelerator-based stereotactic radiosurgery for trigeminal neuralgia.Surgical neurology international · 2026Article
- Purine Metabolism-Related Pathogenic Genes in Trigeminal Neuralgia: A Multiomics Mendelian Randomization Study.Pain research & management · 2026Article
- Trigger zones in trigeminal neuralgia: clinical features, pathophysiological mechanisms, and therapeutic strategies.Frontiers in neurology · 2026Review
- Carbamazepine improves perioperative outcomes in patients with tentorial meningiomas.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- A mouse model of classical trigeminal neuralgia via intradural compression of the trigeminal nerve.The journal of headache and pain · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trigeminal neuralgia (TN) is a complex orofacial pain syndrome characterized by the paroxysmal onset of pain attacks in the trigeminal distribution. The underlying mechanism for this debilitating condition is still not clearly understood. Decades of basic and clinical evidence support the demyelination hypothesis, where demyelination along the trigeminal afferent pathway is a major driver for TN pathogenesis and pathophysiology. Such pathological demyelination can be triggered by physical compression of the trigeminal ganglion or another primary demyelinating disease, such as multiple sclerosis. Further examination of TN patients and animal models has revealed significant molecular changes, channelopathies, and electrophysiological abnormalities in the affected trigeminal nerve. Interestingly, recent electrophysiological recordings and advanced functional neuroimaging data have shed new light on the global structural changes and the altered connectivity in the central pain-related circuits in TN patients. The current article aims to review the latest findings on the pathophysiology of TN and cross-examining them with the current surgical and pharmacologic management for TN patients. Understanding the underlying biology of TN could help scientists and clinicians to identify novel targets and improve treatments for this complex, debilitating disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.