Evidence map›Paper›PMID 35408948›Full record

ArticleInternational journal of molecular sciences2022

Biological Evaluation of Photodynamic Effect Mediated by Nanoparticles with Embedded Porphyrin Photosensitizer.

Ludmila Žárská, Zuzana Malá, Kateřina Langová, Lukáš Malina, Svatopluk Binder, Robert Bajgar, Petr Henke, Jiří Mosinger, Hana Kolářová

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Ludmila ŽárskáDepartment of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 775 15 Olomouc, Czech Republic.
Zuzana MaláDepartment of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 775 15 Olomouc, Czech Republic.
Kateřina LangováDepartment of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 775 15 Olomouc, Czech Republic.
Lukáš MalinaDepartment of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 775 15 Olomouc, Czech Republic.
Svatopluk BinderDepartment of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 775 15 Olomouc, Czech Republic.
Robert BajgarDepartment of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 775 15 Olomouc, Czech Republic.ORCID 0000-0003-4854-4114
Petr HenkeDepartment of Inorganic Chemistry, Faculty of Science, Charles University, Hlavova 2030, 128 43 Prague, Czech Republic.
Jiří MosingerDepartment of Inorganic Chemistry, Faculty of Science, Charles University, Hlavova 2030, 128 43 Prague, Czech Republic.
Hana KolářováDepartment of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 775 15 Olomouc, Czech Republic.
Palacký University Olomouc · CZCharles University · CZInstitute of Molecular and Translational Medicine · CZ

Funding

Ministry of Health of the Czech Republic NU21-09-00357the European Regional Development Fund CZ.02.1.01/0.0/0.0/16_019/0000868
6 · The paper itself

Abstract

Clinically approved photodynamic therapy (PDT) is a minimally invasive treatment procedure that uses three key components: photosensitization, a light source, and tissue oxygen. However, the photodynamic effect is limited by both the photophysical properties of photosensitizers as well as their low selectivity, leading to damage to adjacent normal tissue and/or inadequate biodistribution. Nanoparticles (NPs) represent a new option for PDT that can overcome most of the limitations of conventional photosensitizers and can also promote photosensitizer accumulation in target cells through enhanced permeation and retention effects. In this in vitro study, the photodynamic effect of TPP photosensitizers embedded in polystyrene nanoparticles was observed on the non-tumor

Indexed as

NanoparticlesPhotochemotherapyPorphyrinsAnimalsCell Line, TumorHumansMiceNIH 3T3 CellsPhotosensitizing AgentsReactive Oxygen SpeciesTissue DistributionPhotosensitizing AgentsPorphyrinsReactive Oxygen Speciescancernanoparticlesphotodynamic effect

Identifiers

PMID35408948
PMCPMC8998438
OpenAlexW4221009255

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.