Evidence map›Paper›PMID 35408888›Full record

ArticleInternational journal of molecular sciences2022

Gut Mucosal Microbiome Is Perturbed in Rheumatoid Arthritis Mice and Partly Restored after TDAG8 Deficiency or Suppression by Salicylanilide Derivative.

Ngoc Tuan Nguyen, Wei-Hsin Sun, Tzu-Hsuan Chen, Po-Chun Tsai, Chih-Chen Chen, Shir-Ly Huang

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Ngoc Tuan NguyenFaculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City 700000, Vietnam.ORCID 0000-0002-1865-6628
Wei-Hsin SunDepartment of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.ORCID 0000-0003-3009-520X
Tzu-Hsuan ChenDepartment of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.ORCID 0000-0001-5832-7434
Po-Chun TsaiInstitute of Microbiology and Immunology, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.
Chih-Chen ChenInstitute of Microbiology and Immunology, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.
Shir-Ly HuangInstitute of Microbiology and Immunology, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.
National Yang Ming Chiao Tung University · TWTon Duc Thang University · VN

Funding

Ministry of Science and Technology, Taiwan 106-2320-B-008-004-MY3Ministry of Science and Technology, Taiwan 109-2320-B-010-010-MY3Ministry of Science and Technology, Taiwan 109-2320-B-010-027-MY3National Health Research Institutes 07A1-MGSP08-037National Health Research Institutes 08A1-MGGP08-037
6 · The paper itself

Abstract

Rheumatoid arthritis (RA), an autoimmune disease, is characterized by chronic joint inflammation and pain. We previously found that the deletion of T-cell death-associated gene 8 (TDAG8) significantly reduces disease severity and pain in RA mice. Whether it is by modulating gut microbiota remains unclear. In this study, 64 intestinal samples of feces, cecal content, and cecal mucus from the complete Freund's adjuvant-induced arthritis mouse models were compared. The

Indexed as

Arthritis, RheumatoidGastrointestinal MicrobiomeMicrobiotaAnimalsBacteriaInflammationMicePainSalicylanilidessalicylanilideSalicylanilidesmicrobial diversitymicrobiomepainrheumatoid arthritisT-cell death-associated gene 8

Identifiers

PMID35408888
PMCPMC8998664
OpenAlexW4220708064

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.