Evidence map›Paper›PMID 35408839›Full record

ReviewInternational journal of molecular sciences2022

Molecular Mechanisms of Cutaneous Squamous Cell Carcinoma.

Matthew L Hedberg, Corbett T Berry, Ata S Moshiri, Yan Xiang, Christopher J Yeh, Cem Attilasoy, Brian C Capell, John T Seykora

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. WWOX maintains epidermal identity and suppresses EMT to prevent aggressive cutaneous squamous cell carcinoma.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Matthew L HedbergAbramson Cancer Center, CAMB Graduate Group, Department of Dermatology, Cutaneous Phenomics and Transcriptomics Core, Penn SBDRC, Perelman School of Medicine, University of Pennsylvania, Room 1011 BRB II/III, 421 Curie Blvd, Philadelphia, PA 19104, USA.ORCID 0000-0002-2810-9724
Corbett T BerryAbramson Cancer Center, CAMB Graduate Group, Department of Dermatology, Cutaneous Phenomics and Transcriptomics Core, Penn SBDRC, Perelman School of Medicine, University of Pennsylvania, Room 1011 BRB II/III, 421 Curie Blvd, Philadelphia, PA 19104, USA.
Ata S MoshiriAbramson Cancer Center, CAMB Graduate Group, Department of Dermatology, Cutaneous Phenomics and Transcriptomics Core, Penn SBDRC, Perelman School of Medicine, University of Pennsylvania, Room 1011 BRB II/III, 421 Curie Blvd, Philadelphia, PA 19104, USA.ORCID 0000-0001-6684-4503
Yan XiangAbramson Cancer Center, CAMB Graduate Group, Department of Dermatology, Cutaneous Phenomics and Transcriptomics Core, Penn SBDRC, Perelman School of Medicine, University of Pennsylvania, Room 1011 BRB II/III, 421 Curie Blvd, Philadelphia, PA 19104, USA.
Christopher J YehAbramson Cancer Center, CAMB Graduate Group, Department of Dermatology, Cutaneous Phenomics and Transcriptomics Core, Penn SBDRC, Perelman School of Medicine, University of Pennsylvania, Room 1011 BRB II/III, 421 Curie Blvd, Philadelphia, PA 19104, USA.
Cem AttilasoyAbramson Cancer Center, CAMB Graduate Group, Department of Dermatology, Cutaneous Phenomics and Transcriptomics Core, Penn SBDRC, Perelman School of Medicine, University of Pennsylvania, Room 1011 BRB II/III, 421 Curie Blvd, Philadelphia, PA 19104, USA.
Brian C CapellAbramson Cancer Center, CAMB Graduate Group, Department of Dermatology, Cutaneous Phenomics and Transcriptomics Core, Penn SBDRC, Perelman School of Medicine, University of Pennsylvania, Room 1011 BRB II/III, 421 Curie Blvd, Philadelphia, PA 19104, USA.
John T SeykoraAbramson Cancer Center, CAMB Graduate Group, Department of Dermatology, Cutaneous Phenomics and Transcriptomics Core, Penn SBDRC, Perelman School of Medicine, University of Pennsylvania, Room 1011 BRB II/III, 421 Curie Blvd, Philadelphia, PA 19104, USA.

Funding

Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI A. Clementina Mesaros · 2006 to 2026
$35.3M
Study Design and Data AnalysisP30AR069589 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth Anne Grice · 2016 to 2026
$8.6M
Epigenetic enhancer control in maintaining homeostasis and preventing carcinogenesis in the epidermisR01AR077615 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI CAPELL, BRIAN · 2020 to 2024
$2.1M
Mechanisms regulating the early stages of UV-induced skin cancerR01ES028114 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI SEYKORA, JOHN T. · 2018 to 2022
$1.8M
NIAMS NIH HHS P30 AR069589NIAMS NIH HHS R01 AR077615NIEHS NIH HHS P30 ES013508NIEHS NIH HHS RO1-ES028114
6 · The paper itself

Abstract

Non-melanoma skin cancers are cutaneous malignancies representing the most common form of cancer in the United States. They are comprised predominantly of basal cell carcinomas and squamous cell carcinomas (cSCC). The incidence of cSCC is increasing, resulting in substantial morbidity and ever higher treatment costs; currently in excess of one billion dollars, per annum. Here, we review research defining the molecular basis and development of cSCC that aims to provide new insights into pathogenesis and drive the development of novel, cost and morbidity saving therapies.

Indexed as

Basal Cell CarcinomaCarcinoma, Squamous CellSkin NeoplasmsHumansIncidenceUnited Statescancer biologygenetics of cancerskin cancersquamous cell carcinoma

Identifiers

PMID35408839
PMCPMC8998533

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.