Evidence map›Paper›PMID 35408828›Full record

ArticleInternational journal of molecular sciences2022

Structural and Biophysical Insights into SPINK1 Bound to Human Cationic Trypsin.

Felix Nagel, Gottfried J Palm, Norman Geist, Thomas C R McDonnell, Anne Susemihl, Britta Girbardt, Julia Mayerle, Markus M Lerch, Michael Lammers, Mihaela Delcea

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Felix NagelBiophysical Chemistry, Institute of Biochemistry, University of Greifswald, 17489 Greifswald, Germany.ORCID 0000-0003-3456-7075
Gottfried J PalmSynthetic and Structural Biochemistry, Institute of Biochemistry, University of Greifswald, 17489 Greifswald, Germany.ORCID 0000-0003-0329-0413
Norman GeistBiophysical Chemistry, Institute of Biochemistry, University of Greifswald, 17489 Greifswald, Germany.ORCID 0000-0001-9671-8882
Thomas C R McDonnellBiochemical Engineering Department, University College London, Bernard Katz, London WC1E 6BT, UK.
Anne SusemihlBiophysical Chemistry, Institute of Biochemistry, University of Greifswald, 17489 Greifswald, Germany.ORCID 0000-0002-6363-9325
Britta GirbardtSynthetic and Structural Biochemistry, Institute of Biochemistry, University of Greifswald, 17489 Greifswald, Germany.
Julia MayerleDepartment of Medicine II, University Hospital Munich, Ludwig-Maximillian University Munich, 81377 Munich, Germany.
Markus M LerchDepartment of Medicine A, University Medicine Greifswald, 17489 Greifswald, Germany.
Michael LammersSynthetic and Structural Biochemistry, Institute of Biochemistry, University of Greifswald, 17489 Greifswald, Germany.ORCID 0000-0003-4168-4640
Mihaela DelceaBiophysical Chemistry, Institute of Biochemistry, University of Greifswald, 17489 Greifswald, Germany.ORCID 0000-0002-0851-9072
Universität Greifswald · DELudwig-Maximilians-Universität München · DEUniversitätsmedizin Greifswald · DEUniversity College London · GB

Funding

European Research Council PredicTOOL (637877)MRF_ MRF-057-0004-RG-MCDO-C0800
6 · The paper itself

Abstract

(1) The serine protease inhibitor Kazal type 1 (SPINK1) inhibits trypsin activity in zymogen granules of pancreatic acinar cells. Several mutations in the

Indexed as

Pancreatitis, ChronicTrypsin Inhibitor, Kazal PancreaticEscherichia coliGenetic Predisposition to DiseaseHumansMutationTrypsinSPINK1 protein, humanTrypsinTrypsin Inhibitor, Kazal Pancreaticcatalytic triadcrystal structureisothermal titration calorimetry (ITC)Kazal inhibitormolecular dynamics simulations (MDS)N34Spancreaspancreatitisprotein–protein interactionserine proteasestandard mechanismsurface plasmon resonance (SPR)

Identifiers

PMID35408828
PMCPMC8998336
OpenAlexW4220836539

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.