Evidence map›Paper›PMID 35408806›Full record

ArticleInternational journal of molecular sciences2022

Diversity-Oriented Synthesis Catalyzed by Diethylaminosulfur-Trifluoride-Preparation of New Antitumor Ecdysteroid Derivatives.

Máté Vágvölgyi, Endre Kocsis, Márta Nové, Nikoletta Szemerédi, Gabriella Spengler, Zoltán Kele, Róbert Berkecz, Tamás Gáti, Gábor Tóth, Attila Hunyadi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 63% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Semisynthetic Ecdysteroid Cinnamate Esters andJournal of natural products · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Máté VágvölgyiInstitute of Pharmacognosy, Interdisciplinary Excellence Centre, University of Szeged, H-6720 Szeged, Hungary.ORCID 0000-0002-2233-9422
Endre KocsisInstitute of Pharmacognosy, Interdisciplinary Excellence Centre, University of Szeged, H-6720 Szeged, Hungary.
Márta NovéDepartment of Medical Microbiology, Albert Szent-Györgyi Health Center and Albert Szent-Györgyi Medical School, University of Szeged, H-6725 Szeged, Hungary.
Nikoletta SzemerédiDepartment of Medical Microbiology, Albert Szent-Györgyi Health Center and Albert Szent-Györgyi Medical School, University of Szeged, H-6725 Szeged, Hungary.ORCID 0000-0002-8638-5815
Gabriella SpenglerDepartment of Medical Microbiology, Albert Szent-Györgyi Health Center and Albert Szent-Györgyi Medical School, University of Szeged, H-6725 Szeged, Hungary.ORCID 0000-0001-8085-0950
Zoltán KeleDepartment of Medical Chemistry, University of Szeged, H-6720 Szeged, Hungary.
Róbert BerkeczInstitute of Pharmaceutical Analysis, University of Szeged, H-6720 Szeged, Hungary.ORCID 0000-0002-9076-2177
Tamás GátiServier Research Institute of Medicinal Chemistry (SRIMC), H-1031 Budapest, Hungary.
Gábor TóthNMR Group, Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, H-1111 Budapest, Hungary.
Attila HunyadiInstitute of Pharmacognosy, Interdisciplinary Excellence Centre, University of Szeged, H-6720 Szeged, Hungary.ORCID 0000-0003-0074-3472
University of Szeged · HUBudapest University of Technology and Economics · HU

Funding

Economic Development and Innovation Operative Program GINOP-2.3.2-15-2016- 00012Hungarian Ministry of Innovation and Technology FEIF/646-4/2021-ITM_SZERZNational Research, Development and Innovation Office K134704
6 · The paper itself

Abstract

Fluorine represents a privileged building block in pharmaceutical chemistry. Diethylaminosulfur-trifluoride (DAST) is a reagent commonly used for replacement of alcoholic hydroxyl groups with fluorine and is also known to catalyze water elimination and cyclic Beckmann-rearrangement type reactions. In this work we aimed to use DAST for diversity-oriented semisynthetic transformation of natural products bearing multiple hydroxyl groups to prepare new bioactive compounds. Four ecdysteroids, including a new constituent of

Indexed as

EcdysteroidsFluorineAnimalsCatalysisDiethylaminesMiceDiethylaminesdiethylaminosulfur trifluorideEcdysteroidsFluorineanticancerBeckmann-rearrangementcyclopropaneDASTecdysteroidfluorinationnatural productNMRsemi-synthesisstructure elucidation

Identifiers

PMID35408806
PMCPMC8998355
OpenAlexW4220892364

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.