Evidence map›Paper›PMID 35408797›Full record

ArticleInternational journal of molecular sciences2022

Sperm Physiological Response to Female Serum-Potential New Insights into the Reproductive Incompatibility Diagnostics.

Aleksandra Łukasiewicz, Kari Huhta, Jarmo Ritari, Juha Peräsaari, Pia Allinen, Marjo Malinen, Annalaura Jokiniemi, Tanja Turunen, Jukka Partanen, Jukka Kekäläinen

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aleksandra ŁukasiewiczDepartment of Environmental and Biological Sciences, University of Eastern Finland, P.O. Box 111, 80101 Joensuu, Finland.ORCID 0000-0001-8038-8700
Kari HuhtaDepartment of Environmental and Biological Sciences, University of Eastern Finland, P.O. Box 111, 80101 Joensuu, Finland.
Jarmo RitariResearch and Development, Finnish Red Cross Blood Service, Haartmaninkatu 8, 00290 Helsinki, Finland.
Juha PeräsaariClinical Laboratory, Finnish Red Cross Blood Service, Kivihaantie 7, 00310 Helsinki, Finland.
Pia AllinenInOva klinikka Oy, Ajurinkatu 16, 70110 Kuopio, Finland.
Marjo MalinenDepartment of Environmental and Biological Sciences, University of Eastern Finland, P.O. Box 111, 80101 Joensuu, Finland.
Annalaura JokiniemiDepartment of Environmental and Biological Sciences, University of Eastern Finland, P.O. Box 111, 80101 Joensuu, Finland.
Tanja TurunenDepartment of Environmental and Biological Sciences, University of Eastern Finland, P.O. Box 111, 80101 Joensuu, Finland.
Jukka PartanenResearch and Development, Finnish Red Cross Blood Service, Haartmaninkatu 8, 00290 Helsinki, Finland.ORCID 0000-0001-6681-4734
Jukka KekäläinenDepartment of Environmental and Biological Sciences, University of Eastern Finland, P.O. Box 111, 80101 Joensuu, Finland.

Funding

Academy of Finland 308485Academy of Finland 327509Academy of Finland 335567
6 · The paper itself

Abstract

Infertility is assumed to arise exclusively from male- and female-dependent pathological factors. However, recent studies have indicated that reproductive failure may also result from the reproductive incompatibility of the partners. Selection against such incompatibilities likely occurs via female-derived reproductive secretions, including follicular fluid (FF), that mediate gamete-level mate choice towards the sperm of specific males. To facilitate potential development of diagnostic tests for human reproductive incompatibility, we examined whether sperm physiological response to female serum indicate male-female compatibility in the presence of FF. We performed a full-factorial experiment, in which the sperm of 10 males were treated with the FF and serum of 6 healthy females. We found that sperm motility and viability in both biofluids were highly similar and that in 70% of the males, sperm serum treatment predicted male-female compatibility. We also identified male human leucocyte antigen (HLA) alleles and female (FF and serum) anti-HLA antibodies and tested whether the number of allele-antibody matches predict sperm physiological response to female fluids. However, no association was found between measured sperm traits and the number of allele-antibody matches. Overall, the present results may open novel possibilities for the future development of reproductive incompatibility tests and may pave the way towards more accurate infertility diagnostics and treatments.

Indexed as

InfertilitySperm MotilityFemaleGerm CellsHumansMaleReproductionSpermatozoacryptic female choiceegg donorfertilizationgenetic compatibilityinfertilityMHCsexual selectionsperm function

Identifiers

PMID35408797
PMCPMC8998597

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.