Evidence map›Paper›PMID 35408759›Full record

ArticleMolecules (Basel, Switzerland)2022

Synthesis of Novel C/D Ring Modified Bile Acids.

Roselis A Landaeta Aponte, Andreas Luxenburger, Scott A Cameron, Alex Weymouth-Wilson, Richard H Furneaux, Lawrence D Harris, Benjamin J Compton

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. 3α,7-Dihydroxy-14(13→12)Biomolecules · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Roselis A Landaeta AponteFerrier Research Institute, Victoria University of Wellington, Lower Hutt 5010, New Zealand.
Andreas LuxenburgerFerrier Research Institute, Victoria University of Wellington, Lower Hutt 5010, New Zealand.ORCID 0000-0002-7574-8027
Scott A CameronFerrier Research Institute, Victoria University of Wellington, Lower Hutt 5010, New Zealand.
Alex Weymouth-WilsonICE Group, New Zealand Pharmaceuticals Ltd., 68 Weld Street, RD2, Palmerston North 4472, New Zealand.
Richard H FurneauxFerrier Research Institute, Victoria University of Wellington, Lower Hutt 5010, New Zealand.
Lawrence D HarrisFerrier Research Institute, Victoria University of Wellington, Lower Hutt 5010, New Zealand.ORCID 0000-0002-4214-1018
Benjamin J ComptonFerrier Research Institute, Victoria University of Wellington, Lower Hutt 5010, New Zealand.ORCID 0000-0002-5245-9767
Victoria University of Wellington · NZPharmac · NZ

Funding

New Zealand Ministry of Business, Innovation and Employment RTVU1202
6 · The paper itself

Abstract

Bile acid receptors have been identified as important targets for the development of new therapeutics to treat various metabolic and inflammatory diseases. The synthesis of new bile acid analogues can help elucidate structure-activity relationships and define compounds that activate these receptors selectively. Towards this, access to large quantities of a chenodeoxycholic acid derivative bearing a

Indexed as

Bile Acids and SaltsChenodeoxycholic AcidOxidation-ReductionSteroidsStructure-Activity RelationshipBile Acids and SaltsChenodeoxycholic AcidSteroidsbile acidcyclopropanedrug discoveryrearrangementzinc carbenoids

Identifiers

PMID35408759
PMCPMC9000252
OpenAlexW4223549721

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.