Evidence map›Paper›PMID 35408692›Full record

ArticleMolecules (Basel, Switzerland)2022

Synthesis, Characterization, and In Vivo Study of Some Novel 3,4,5-Trimethoxybenzylidene-hydrazinecarbothioamides and Thiadiazoles as Anti-Apoptotic Caspase-3 Inhibitors.

Sara M Mostafa, Ashraf A Aly, Stefan Bräse, Martin Nieger, Sara Mohamed Naguib Abdelhafez, Walaa Yehia Abdelzaher, El-Shimaa M N Abdelhafez

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sara M MostafaChemistry Department, Faculty of Science, Minia University, El-Minia 61519, Egypt.
Ashraf A AlyChemistry Department, Faculty of Science, Minia University, El-Minia 61519, Egypt.
Stefan BräseInstitute of Organic Chemistry, Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany.ORCID 0000-0003-4845-3191
Martin NiegerDepartment of Chemistry, University of Helsinki, P.O. Box 55 (A. I. Virtasen aukio I), 00014 Helsinki, Finland.
Sara Mohamed Naguib AbdelhafezDepartment of Histology, Faculty of Medicine, Minia University, El-Minia 61519, Egypt.
Walaa Yehia AbdelzaherDepartment of Pharmacology, Faculty of Medicine, Minia University, El-Minia 61519, Egypt.ORCID 0000-0001-6511-1797
El-Shimaa M N AbdelhafezDepartment of Medicinal Chemistry, Faculty of Pharmacy, Minia University, El-Minia 61519, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study aims to discover novel derivatives as antiapoptotic agents and their protective effects against renal ischemia/reperfusion. Therefore, a series of new thiadiazole analogues

Indexed as

Caspase 3Caspase InhibitorsThiadiazolesAnimalsApoptosisCytochromes cMolecular Docking SimulationRatsStructure-Activity RelationshipCaspase 3Caspase InhibitorsCytochromes cThiadiazolesantiapoptotic activitycaspase-3histochemical staininghydrazinecarbothioamidesmolecular dockingselectivitythiadiazoles

Identifiers

PMID35408692
PMCPMC9040718

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.