Evidence map›Paper›PMID 35408684›Full record

ArticleMolecules (Basel, Switzerland)2022

Ligand and Structure-Based In Silico Determination of the Most Promising SARS-CoV-2 nsp16-nsp10 2'-

Ibrahim H Eissa, Mohamed S Alesawy, Abdulrahman M Saleh, Eslam B Elkaeed, Bshra A Alsfouk, Abdul-Aziz M M El-Attar, Ahmed M Metwaly

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
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  3. Article
  4. Article
  5. Article
  6. PeerJ · 2024
    Article
  7. Article
  8. PeerJ · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. New Anticancer Theobromine Derivative Targeting EGFRMolecules (Basel, Switzerland) · 2022
    Article
  15. Review
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ibrahim H EissaPharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt.ORCID 0000-0002-6955-2263
Mohamed S AlesawyPharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt.ORCID 0000-0001-9202-1754
Abdulrahman M SalehPharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt.ORCID 0000-0002-5153-7399
Eslam B ElkaeedDepartment of Pharmaceutical Sciences, College of Pharmacy, Almaarefa University, Riyadh 13713, Saudi Arabia.ORCID 0000-0002-2546-8035
Bshra A AlsfoukDepartment of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.ORCID 0000-0001-6489-6035
Abdul-Aziz M M El-AttarPharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo 11884, Egypt.
Ahmed M MetwalyPharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt.ORCID 0000-0001-8566-1980

Funding

Princess Nourah bint Abdulrahman University PNURSP2022R142
6 · The paper itself

Abstract

As a continuation of our earlier work against SARS-CoV-2, seven FDA-approved drugs were designated as the best SARS-CoV-2 nsp16-nsp10 2'-

Indexed as

MethyltransferasesSARS-CoV-2Viral Nonstructural ProteinsViral Regulatory and Accessory ProteinsErtapenemLigandsMolecular Docking SimulationMolecular Dynamics SimulationS-AdenosylmethionineErtapenemLigandsMethyltransferasesNSP16 protein, SARS-CoV-2ORF1ab polyprotein, SARS-CoV-2S-AdenosylmethionineViral Nonstructural ProteinsViral Regulatory and Accessory ProteinsFDA approved drugsMD simulationsMMPBSAmolecular dockingmolecular fingerprintsSARS-CoV-2 nsp16-nsp10 2′-o-methyltransferasestructural similarity

Identifiers

PMID35408684
PMCPMC9000629

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.