Evidence map›Paper›PMID 35408611›Full record

ArticleMolecules (Basel, Switzerland)2022

Potential Therapeutic Target Protein Tyrosine Phosphatase-1B for Modulation of Insulin Resistance with Polyphenols and Its Quantitative Structure-Activity Relationship.

Prangya Rath, Anuj Ranjan, Arabinda Ghosh, Abhishek Chauhan, Manisha Gurnani, Hardeep Singh Tuli, Hamza Habeeballah, Mustfa F Alkhanani, Shafiul Haque, Kuldeep Dhama and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 18 citations in OpenAlex.

  1. Antidiabetic Properties ofLife (Basel, Switzerland) · 2026
    Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 4 countries.

Prangya RathAmity Institute of Environmental Sciences, Amity University, Noida 201303, India.ORCID 0000-0002-6764-1625
Anuj RanjanAcademy of Biology and Biotechnology, Southern Federal University, 344006 Rostov-on-Don, Russia.ORCID 0000-0003-2592-9716
Arabinda GhoshMicrobiology Division, Department of Botany, Gauhati University, Guwahati 781014, India.ORCID 0000-0002-3891-5949
Abhishek ChauhanAmity Institute of Environmental Toxicology Safety and Management, Amity University, Noida 201303, India.
Manisha GurnaniAmity Institute of Environmental Sciences, Amity University, Noida 201303, India.ORCID 0000-0002-8913-4683
Hardeep Singh TuliDepartment of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala 133207, India.ORCID 0000-0003-1155-0094
Hamza HabeeballahFaculty of Applied Medical Sciences, King Abdulaziz University, Rabigh Branch, Rabigh 25732, Saudi Arabia.
Mustfa F AlkhananiEmergency Service Department, College of Applied Sciences, AlMaarefa University, Riyadh 11597, Saudi Arabia.
Shafiul HaqueResearch and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan 45142, Saudi Arabia.ORCID 0000-0002-2989-121X
Kuldeep DhamaDivision of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly 243122, India.ORCID 0000-0001-7469-4752
Naval Kumar VermaHomeopathy, Ministry of Ayush, Ayush Bhawan, B Block, GPO Complex INA, New Delhi 110023, India.
Tanu JindalAmity Institute of Environmental Toxicology Safety and Management, Amity University, Noida 201303, India.
Amity University · INAlfaisal University · SABursa Uludağ Üni̇versi̇tesi̇ · TRGauhati University · INIndian Veterinary Research Institute · INKing Abdulaziz University · SAMaharishi Markandeshwar University, Mullana · INMinistry of AYUSH · INSouthern Federal University · RU

Funding

AlMaarefa University, Riyadh, Saudi Arabia TUMA-2021-53
6 · The paper itself

Abstract

The increase in the number of cases of type 2 diabetes mellitus (T2DM) and the complications associated with the side effects of chemical/synthetic drugs have raised concerns about the safety of the drugs. Hence, there is an urgent need to explore and identify natural bioactive compounds as alternative drugs. Protein tyrosine phosphatase 1B (PTP1B) functions as a negative regulator and is therefore considered as one of the key protein targets modulating insulin signaling and insulin resistance. This article deals with the screening of a database of polyphenols against PTP1B activity for the identification of a potential inhibitor. The research plan had two clear objectives. Under first objective, we conducted a quantitative structure-activity relationship analysis of flavonoids with PTP1B that revealed the strongest correlation (R

Indexed as

Diabetes Mellitus, Type 2Insulin ResistanceEnzyme InhibitorsHumansMolecular Docking SimulationPolyphenolsProtein Tyrosine Phosphatase, Non-Receptor Type 1Quantitative Structure-Activity RelationshipStructure-Activity RelationshipEnzyme InhibitorsPolyphenolsProtein Tyrosine Phosphatase, Non-Receptor Type 1catalytic active sitediabetesdockinginsulin resistancemolecular dynamic simulationpolyphenolsQSAR

Identifiers

PMID35408611
PMCPMC9000704
OpenAlexW4221122216

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.