ArticleMolecules (Basel, Switzerland)2022
Facile Amidation of Non-Protected Hydroxycinnamic Acids for the Synthesis of Natural Phenol Amides.
Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 19 citations in OpenAlex.
- Natural Strategies to Preserve Alcohol-Free Beer: Phenolamide Dimers with Anti-Yeast Potential.Journal of agricultural and food chemistry · 2026Article
- Synthesis of Avenanthramide C and Its Analogs Utilizing Classical Condensation, Saponification and Acidification.ACS omega · 2026Article
- Two-Step Flow Amidation of Natural Phenolic Acids as Antiradical and Antimicrobial Agents.Journal of natural products · 2025Article
- Comment on "Three New Dimers and Two Monomers of Phenolic Amides from the Fruits ofJournal of agricultural and food chemistry · 2024Article
- Metabolite Profiling ofNutrients · 2023Article
- Synthesis of Furan-Based Diamine and Its Application in the Preparation of Bio-Based Polyimide.Polymers · 2023Article
- Biomimetic Enzymatic Oxidative Coupling of Barley Phenolamides: Hydroxycinnamoylagmatines.Journal of agricultural and food chemistry · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Phenol amides are bioactive compounds naturally present in many plants. This class of compounds is known for antioxidant, anti-inflammatory, and anticancer activities. To better understand the reactivity and structure-bioactivity relationships of phenol amides, a large set of structurally diverse pure compounds are needed, however purification from plants is inefficient and laborious. Existing syntheses require multiple steps, including protection of functional groups and are generally overly complicated and only suitable for specific combinations of hydroxycinnamic acid and amine. Thus, to facilitate further studies on these promising compounds, we aimed to develop a facile general synthetic route to obtain phenol amides with a wide structural diversity. The result is a protocol for straightforward one-pot synthesis of phenol amides at room temperature within 25 h using equimolar amounts of
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Registered trials
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