Evidence map›Paper›PMID 35408598›Full record

ArticleMolecules (Basel, Switzerland)2022

Synthesis of Phosphatidyl Glycerol Containing Unsymmetric Acyl Chains Using H-Phosphonate Methodology.

Zachary J Struzik, Shruti Biyani, Tim Grotzer, Judith Storch, David H Thompson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Zachary J StruzikBindley Bioscience Center, Department of Chemistry, Multi-Disciplinary Cancer Research Facility, Purdue University, 1203 W. State Street, West Lafayette, IN 47907, USA.ORCID 0000-0002-2560-173X
Shruti BiyaniBindley Bioscience Center, Department of Chemistry, Multi-Disciplinary Cancer Research Facility, Purdue University, 1203 W. State Street, West Lafayette, IN 47907, USA.
Tim GrotzerBindley Bioscience Center, Department of Chemistry, Multi-Disciplinary Cancer Research Facility, Purdue University, 1203 W. State Street, West Lafayette, IN 47907, USA.
Judith StorchDepartment of Nutritional Sciences and Rutgers Center for Lipid Research, Rutgers University, New Brunswick, NJ 08901, USA.ORCID 0000-0001-5482-1777
David H ThompsonBindley Bioscience Center, Department of Chemistry, Multi-Disciplinary Cancer Research Facility, Purdue University, 1203 W. State Street, West Lafayette, IN 47907, USA.ORCID 0000-0002-0746-1526
State Street (United States) · USRutgers, The State University of New Jersey · US

Funding

Mechanisms of Cholesterol Transport by NPC ProteinsR01GM115866 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI STORCH, JUDITH · 2016 to 2019
$1.1M
NIGMS NIH HHS R01 GM115866NIH HHS R01GM1125866
6 · The paper itself

Abstract

Naturally occurring phospholipids, such as phosphatidyl glycerol (PG), are gaining interest due to the roles they play in disease mechanisms. To elucidate the metabolism of PG, an optically pure material is required, but this is unfortunately not commercially available. Our previous PG synthesis route utilized phosphoramidite methodology that addressed issues surrounding fatty acid substrate scope and glycerol backbone modifications prior to headgroup phosphorylation, but faltered in the reproducibility of the overall pathway due to purification challenges. Herein, we present a robust pathway to optically pure PG in fewer steps, utilizing H-phosphonates that features a chromatographically friendly and stable triethyl ammonium H-phosphonate salt. Our route is also amendable to the simultaneous installation of different acyl chains, either saturated or unsaturated, on the glycerol backbone.

Indexed as

OrganophosphonatesPhosphatidylglycerolsFatty AcidsGlycerolPhospholipidsReproducibility of ResultsFatty AcidsGlycerolOrganophosphonatesPhosphatidylglycerolsPhospholipidsH-phosphonatesphosphatidyl glycerolphospholipid synthesisphosphoramidites

Identifiers

PMID35408598
PMCPMC9000858
OpenAlexW4220708490

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.