Evidence map›Paper›PMID 35408572›Full record

ArticleMolecules (Basel, Switzerland)2022

Computational Methods for Understanding the Selectivity and Signal Transduction Mechanism of Aminomethyl Tetrahydronaphthalene to Opioid Receptors.

Peng Xie, Junjie Zhang, Baiyu Chen, Xinwei Li, Wenbo Zhang, Mengdan Zhu, Wei Li, Jianqi Li, Wei Fu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Peng XieSchool of Pharmacy, Fudan University, Shanghai 201301, China.
Junjie ZhangSchool of Pharmacy, Fudan University, Shanghai 201301, China.
Baiyu ChenSchool of Pharmacy, Fudan University, Shanghai 201301, China.
Xinwei LiSchool of Pharmacy, Fudan University, Shanghai 201301, China.
Wenbo ZhangNovel Technology Center of Chemical Pharmaceutics, Shanghai Institute of Pharmaceutical Industry Co., Ltd., China State Institute of Pharmaceutical Industry Co., Ltd., Shanghai 201203, China.
Mengdan ZhuSchool of Pharmacy, Fudan University, Shanghai 201301, China.
Wei LiSchool of Pharmacy, Fudan University, Shanghai 201301, China.
Jianqi LiNovel Technology Center of Chemical Pharmaceutics, Shanghai Institute of Pharmaceutical Industry Co., Ltd., China State Institute of Pharmaceutical Industry Co., Ltd., Shanghai 201203, China.
Wei FuSchool of Pharmacy, Fudan University, Shanghai 201301, China.
Fudan University · CNShanghai Institute of Pharmaceutical Industry · CN

Funding

National Natural Science Foundation of China NO. 82073765 and 81773635Shanghai Science and Technology Development Funds 19431900500 and 20S11902400
6 · The paper itself

Abstract

Opioid receptors are members of the group of G protein-couple receptors, which have been proven to be effective targets for treating severe pain. The interactions between the opioid receptors and corresponding ligands and the receptor's activation by different agonists have been among the most important fields in opioid research. In this study, with compound

Indexed as

Receptors, OpioidReceptors, Opioid, deltaMolecular Dynamics SimulationReceptors, Opioid, muSignal TransductionStructure-Activity RelationshipTetrahydronaphthalenesReceptors, OpioidReceptors, Opioid, deltaReceptors, Opioid, muTetrahydronaphthalenesactivation mechanismmolecular dynamics simulationselectivitysignal transduction mechanismδ-opioid receptorκ-opioid receptorμ-opioid receptor

Identifiers

PMID35408572
PMCPMC9000250
OpenAlexW4220912712

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.