Evidence map›Paper›PMID 35408567›Full record

ArticleMolecules (Basel, Switzerland)2022

New Organic Salt from Levofloxacin-Citric Acid: What Is the Impact on the Stability and Antibiotic Potency?

Ilma Nugrahani, Agnesya Namira Laksana, Hidehiro Uekusa, Hironaga Oyama

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Frontiers in cellular and infection microbiology · 2026
    Article
  3. Crystal structure and Hirshfeld surface analysis of anhydrous salt of levofloxacin and 4-methyl-benzoic acid.Acta crystallographica. Section E, Crystallographic communications · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Non-Covalent Reactions Supporting Antiviral Development.Molecules (Basel, Switzerland) · 2022
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ilma NugrahaniSchool of Pharmacy, Bandung Institute of Technology, Bandung 40132, Indonesia.ORCID 0000-0001-5069-0343
Agnesya Namira LaksanaSchool of Pharmacy, Bandung Institute of Technology, Bandung 40132, Indonesia.
Hidehiro UekusaDepartment of Chemistry, School of Science, Tokyo Institute of Technology, Tokyo 152-8551, Japan.ORCID 0000-0001-9809-1411
Hironaga OyamaDepartment of Chemistry, School of Science, Tokyo Institute of Technology, Tokyo 152-8551, Japan.

Funding

Bandung Institute of Technology 3249/IT1.B07.1/TA.00/2021 (IN) and JSPS KAKENHI Grant number JP18H04504 and 20H04661 (HU).Tokyo Institute of Technology JSPS KAKENHI Grant number JP18H04504 and 20H04661 (HU).
6 · The paper itself

Abstract

This research dealt with the composition, structure determination, stability, and antibiotic potency of a novel organic salt composed of levofloxacin (LF) and citric acid (CA), named levofloxacin-citrate (LC). After a stoichiometric proportion screening, the antibiotic-antioxidant reaction was conducted by slow and fast evaporation methods. A series of characterizations using thermal analysis, powder X-ray diffractometry, vibrational spectroscopy, and nuclear magnetic resonance confirmed LC formation. The new organic salt showed a distinct thermogram and diffractogram. Next, Fourier transform infrared indicated the change in

Indexed as

Citric AcidLevofloxacinAnti-Bacterial AgentsAntioxidantsSpectroscopy, Fourier Transform InfraredAnti-Bacterial AgentsAntioxidantsCitric AcidLevofloxacinantibiotic potencycitric acidlevofloxacinlevofloxacin-citrateorganic saltstability

Identifiers

PMID35408567
PMCPMC9000237

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.