Untargeted Metabolomics Reveals the Potential Antidepressant Activity of a Novel Adenosine Receptor Antagonist.

Arnold Petrus Smith, Jeremie Zander Lindeque, Mietha Magdalena van der Walt

Open access · goldAbstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.3field-weighted citation impact, top 59% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

Functional and Structural Insights into Lipases Associated with Fruit Lipid Accumulation inBiomolecules · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Arnold Petrus SmithHuman Metabolomics, Faculty of Natural and Agricultural Sciences, Potchefstroom Campus, North-West University, Private Bag x6001, Box 269, Potchefstroom 2531, South Africa.ORCID 0000-0001-8098-799X

Jeremie Zander LindequeHuman Metabolomics, Faculty of Natural and Agricultural Sciences, Potchefstroom Campus, North-West University, Private Bag x6001, Box 269, Potchefstroom 2531, South Africa.ORCID 0000-0001-8017-4278

Mietha Magdalena van der WaltHuman Metabolomics, Faculty of Natural and Agricultural Sciences, Potchefstroom Campus, North-West University, Private Bag x6001, Box 269, Potchefstroom 2531, South Africa.ORCID 0000-0002-1518-3925

North-West University · ZA

Funding

National Research Foundation (NRF) of South Africa 120429

6 · The paper itself

Abstract

Depression is the most common mental illness, affecting approximately 4.4% of the global population. Despite many available treatments, some patients exhibit treatment-resistant depression. Thus, the need to develop new and alternative treatments cannot be overstated. Adenosine receptor antagonists have emerged as a promising new class of antidepressants. The current study investigates a novel dual A

Indexed as

Adenosine A2 Receptor AntagonistsPurinergic P1 Receptor AntagonistsAnimalsAntidepressive AgentsDepressionHumansMaleMetabolomicsPurine NucleosidesRatsRats, Sprague-DawleyAdenosine A2 Receptor AntagonistsAntidepressive AgentsPurine NucleosidesPurinergic P1 Receptor Antagonists1H-NMRadenosine receptorantagonistdepressionGC-TOFMSimipramineKW-6002untargeted metabolomics

Identifiers

PMID35408500

DOI10.3390/molecules27072094

PMCPMC9000263

OpenAlexW4221081583

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.