Evidence map›Paper›PMID 35408446›Full record

ArticleMolecules (Basel, Switzerland)2022

Novel 1,2,3-Triazole-Coumarin Hybrid Glycosides and Their Tetrazolyl Analogues: Design, Anticancer Evaluation and Molecular Docking Targeting EGFR, VEGFR-2 and CDK-2.

Wael A El-Sayed, Fahad M Alminderej, Marwa M Mounier, Eman S Nossier, Sayed M Saleh, Asmaa F Kassem

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 56 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Coumarin: A natural solution for alleviating inflammatory disorders.Current research in pharmacology and drug discovery · 2024
    Review
  7. Article
  8. Article
  9. Synthesis and Properties of (1International journal of molecular sciences · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Synthesis of 4,5-Dihydro-1Molecules (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Wael A El-SayedDepartment of Chemistry, College of Science, Qassim University, Buraidah 51452, Saudi Arabia.
Fahad M AlminderejDepartment of Chemistry, College of Science, Qassim University, Buraidah 51452, Saudi Arabia.
Marwa M MounierDepartment of Pharmacognosy, National Research Centre, Giza 12622, Egypt.ORCID 0000-0003-1584-9245
Eman S NossierDepartment of Pharmaceutical Medicinal Chemistry and Drug Design, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11754, Egypt.ORCID 0000-0001-6159-5333
Sayed M SalehDepartment of Chemistry, College of Science, Qassim University, Buraidah 51452, Saudi Arabia.ORCID 0000-0002-2677-0439
Asmaa F KassemDepartment of Chemistry of Natural and Microbial Products, National Research Centre, Cairo 12622, Egypt.
National Research Centre · EGQassim University · SAAl-Azhar University · EGSuez University · EG

Funding

Qassim University 10191-cos-2020-1-3-I
6 · The paper itself

Abstract

This study represents the design and synthesis of a new set of triazole-coumarin-glycosyl hybrids and their tetrazole hybrid analogues possessing various sugar moieties and modified analogues. All the newly synthesized derivatives were screened for their cytotoxic activities against a panel of human cancer cell lines. The coumarin derivatives

Indexed as

Antineoplastic AgentsVascular Endothelial Growth Factor Receptor-2Cell ProliferationCoumarinsDrug Screening Assays, AntitumorErbB ReceptorsGlycosidesHumansMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipTriazolesAntineoplastic AgentscoumarinCoumarinsEGFR protein, humanErbB ReceptorsGlycosidesTriazolesVascular Endothelial Growth Factor Receptor-21,2,3-triazolesanticancerCDK-2coumarinEGFRglycosidesmolecular dockingtetrazoles

Identifiers

PMID35408446
PMCPMC9000887
OpenAlexW4223550910

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.