ArticleMolecules (Basel, Switzerland)2022
Fibrinogen Concentrations in Liquid PRF Using Various Centrifugation Protocols.
Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Sticky bone in regenerative dentistry: a paradigm shift in graft stability or a promising technique still under scrutiny?Annals of medicine and surgery (2012) · 2026Review
- Advantages of horizontal centrifugation of platelet-rich fibrin in regenerative medicine and dentistry.Periodontology 2000 · 2025Review
- Tooth Autotransplantation, Autogenous Dentin Graft, and Growth Factors Application: A Method for Preserving the Alveolar Ridge in Cases of Severe Infraocclusion-A Case Report and Literature Review.Journal of clinical medicine · 2024Article
- Investigation of three common centrifugation protocols for platelet-rich fibrin (PRF) as a bio-carrier for ampicillin/sulbactam: a prospective trial.Clinical oral investigations · 2023Article
- Early tissue and healing responses after maxillary sinus augmentation using horizontal platelet rich fibrin bone blocks.BMC oral health · 2023Article
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- Lipids of Platelet-Rich Fibrin Reduce the Inflammatory Response in Mesenchymal Cells and Macrophages.Cells · 2023Article
- Biomolecular and Biochemical Aspects of the Oral Cavity.Molecules (Basel, Switzerland) · 2022Article
- Platelet-Rich Fibrin Reduces IL-1β Release from Macrophages Undergoing Pyroptosis.International journal of molecular sciences · 2022Article
- Blood Clots versus PRF: Activating TGF-β Signaling and Inhibiting Inflammation In Vitro.International journal of molecular sciences · 2022Article
- Comparison of Fibrin Characteristics and Cellular Contents of Injectable Platelet-rich Fibrin Enriched Bone Block ("Sticky Bone") Prepared Using Novel and Traditional Protocols - AnContemporary clinical dentistryArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Liquid platelet-rich fibrin (PRF) is produced by fractionation of blood without additives that initiate coagulation. Even though liquid PRF is frequently utilized as a natural source of fibrinogen to prepare sticky bone, the concentration of fibrinogen and the overall amount of "clottable PRF" components have not been evaluated. To this aim, we prepared liquid PRF at 300, 700, and 2000 relative centrifugal force (RCF), for 8 min and quantified the fibrinogen levels by immunoassay. We report here that, independent of the RCF, the fibrinogen concentration is higher in the platelet-poor plasma (PPP) compared to the buffy coat (BC) fraction of liquid PRF and further decreases in the remaining red fraction. We then determined the weight of the clotted PRF fractions before and after removing the serum. The PPP and BC fractions consist of 10.2% and 25.3% clottable matrix suggesting that more than half of the weight of clottable BC is caused by cellular components. Our data provide insights into the distribution of fibrinogen in the different fractions of liquid PRF. These findings suggest that PPP is the main source of clottable fibrinogen, while the BC is more a cell source when it comes to the preparation of sticky bone.
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Registered trials
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