Evidence map›Paper›PMID 35407539›Full record

ArticleJournal of clinical medicine2022

Effect of MAO-B Inhibitors on Neurometabolic Profile of Patients Affected by Parkinson Disease: A Proton Magnetic Resonance Spectroscopy Study.

Lilla Bonanno, Rosella Ciurleo, Silvia Marino, Claudio Ruvolo, Rosa Morabito, Alessia Bramanti, Francesco Corallo

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. UsingInternational journal of molecular sciences · 2025
    Pooled it
  2. Taurochenodeoxycholic acid alleviates MPPIBRO neuroscience reports · 2026
    Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Lilla BonannoNeuroimaging Laboratory, IRCCS Centro Neurolesi Bonino-Pulejo, 98124 Messina, Italy.ORCID 0000-0002-0282-405X
Rosella CiurleoNeuroimaging Laboratory, IRCCS Centro Neurolesi Bonino-Pulejo, 98124 Messina, Italy.
Silvia MarinoNeuroimaging Laboratory, IRCCS Centro Neurolesi Bonino-Pulejo, 98124 Messina, Italy.
Claudio RuvoloNeuroimaging Laboratory, IRCCS Centro Neurolesi Bonino-Pulejo, 98124 Messina, Italy.
Rosa MorabitoNeuroimaging Laboratory, IRCCS Centro Neurolesi Bonino-Pulejo, 98124 Messina, Italy.
Alessia BramantiDepartment of Medicine Surgery and Dentistry 'Salerno Medical School', University of Salerno, 84084 Fisciano, Italy.
Francesco CoralloNeuroimaging Laboratory, IRCCS Centro Neurolesi Bonino-Pulejo, 98124 Messina, Italy.
Centro Neurolesi Bonino Pulejo · ITUniversity of Salerno · IT

Funding

Italian Health Minister GR-2013-02359069
6 · The paper itself

Abstract

Parkinson's Disease (PD) is the most common neurodegenerative movement disorder whose treatment is symptomatic. No suitable methods for assessing the effects of dopaminergic drugs on disease progression in clinical trials have yet been provided. The aim of this longitudinal study is to evaluate the influence of rasagiline and selegiline on neurometabolic profile in de novo PD patients by using Proton Magnetic Resonance Spectroscopy (

Indexed as

cerebral cortexcholinedisease progressionMAO-B inhibitorsN-acetylaspartateneurometabolitesParkinson’s diseaseproton magnetic resonance spectroscopyrasagilineselegiline

Identifiers

PMID35407539
PMCPMC8999805
OpenAlexW4221081007

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.