Evidence map›Paper›PMID 35407436›Full record

ArticleJournal of clinical medicine2022

Macular Pigment and Open-Angle Glaucoma in the Elderly: The Montrachet Population-Based Study.

Louis Arnould, Alassane Seydou, Christine Binquet, Pierre-Henry Gabrielle, Chloé Chamard, Lionel Bretillon, Alain M Bron, Niyazi Acar, Catherine Creuzot-Garcher

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Going for Gaps in Glaucoma.Journal of clinical medicine · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Louis ArnouldDepartment of Ophthalmology, Dijon University Hospital, 21000 Dijon, France.ORCID 0000-0001-7831-8818
Alassane SeydouCentre des Sciences du Goût et de l'Alimentation, AgroSup Dijon, CNRS, INRAE, Université Bourgogne Franche-Comté, 21000 Dijon, France.
Christine BinquetClinical Epidemiology/Clinical Trials Unit, Clinical Investigation Center, INSERM, CIC 1432, Dijon University Hospital, 21000 Dijon, France.ORCID 0000-0002-9417-5754
Pierre-Henry GabrielleDepartment of Ophthalmology, Dijon University Hospital, 21000 Dijon, France.ORCID 0000-0002-9688-4845
Chloé ChamardDepartment of Ophthalmology, Gui de Chauliac Hospital, 34000 Montpellier, France.
Lionel BretillonCentre des Sciences du Goût et de l'Alimentation, AgroSup Dijon, CNRS, INRAE, Université Bourgogne Franche-Comté, 21000 Dijon, France.ORCID 0000-0002-6957-100X
Alain M BronDepartment of Ophthalmology, Dijon University Hospital, 21000 Dijon, France.ORCID 0000-0002-7265-931X
Niyazi AcarCentre des Sciences du Goût et de l'Alimentation, AgroSup Dijon, CNRS, INRAE, Université Bourgogne Franche-Comté, 21000 Dijon, France.ORCID 0000-0002-3401-8079
Catherine Creuzot-GarcherDepartment of Ophthalmology, Dijon University Hospital, 21000 Dijon, France.
Centre National de la Recherche Scientifique · FRInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: To compare macular pigment optical density (MPOD) and its spatial distribution between eyes with primary open-angle glaucoma (POAG) and control eyes in an elderly population. (2) Methods: The Montrachet study (Maculopathy Optic Nerve and nutrition neurovAsCular and HEarT) is a population-based study including participants aged 75 years and over. All participants had a slit lamp examination, fundus photographs, and a questionnaire about their medical past history and smoking status. Optic disc spectral domain optical coherence tomography was also performed. All glaucoma-suspected patients were convocated to have a new full examination. We only retained one eye with POAG for analysis in the glaucoma group and one eye without optic neuropathy in the control participants group. MPOD measurements were performed with the two-wavelength autofluorescence method (488 and 514 nm). (3) Results: Overall, 601 eyes had MPOD measurements among 1153 participants. Among the 601 eyes, 48 had POAG. The mean age for the glaucoma and control participants was 84.01 ± 4.22 years and 81.94 ± 3.61 years, respectively (p < 0.001). In the multivariable analysis, we could not find any association between POAG and MPOD at 0.5° (p = 0.336). We found no significant difference regarding MP spatial distribution between the two groups (p = 0.408). (4) Conclusion: In this elderly population-based study, eyes with POAG and control eyes without optic neuropathy did not differ in terms of MPOD and MP spatial distribution.

Indexed as

elderlyglaucomamcular pigment optical densitypopulation-based studytwo-wavelength autofluorescence

Identifiers

PMID35407436
PMCPMC8999647
OpenAlexW4220667912

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.