ArticleJournal of clinical medicine2022
Comparative Longitudinal Analysis of Malignant Transformation in Pleomorphic Adenoma and Recurrent Pleomorphic Adenoma.
Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical behavior of recurrent pleomorphic adenoma in the palate: a systematic review.Acta cirurgica brasileira · 2024Pooled it
- Recurrent Pleomorphic Adenoma of the Palate: A Case Report.Clinics and practice · 2026Article
- The paradox of benign histology and malignant behavior: lymphatic metastasis in pleomorphic adenoma-a case report.Journal of medical case reports · 2026Article
- Massive Recurrent Parotid Carcinoma in a 90-Year-Old Patient: A Case Report and Review of Management Strategies.Cureus · 2026Article
- Clinicopathologic Features and Postoperative Outcomes of Parotidectomy: A 16-Year Retrospective Cohort Study from a Tertiary Referral Center.Diagnostics (Basel, Switzerland) · 2026Article
- Large Pleomorphic Adenoma of The Upper Lip in a Middle-Aged Woman With Facial Deformity, Tooth Displacement, and Bone Loss: Uncommon Clinical Presentation of a Benign Tumor.Case reports in dentistry · 2026Article
- Role of fine needle aspiration biopsy in the diagnosis of pleomorphic adenoma.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2025Article
- Case Report: Carcinoma Ex-Pleomorphic Adenoma With Concurrent Submandibular Gland Lithiasis-A Rare Association With Potential Pathophysiological Implications.Clinical case reports · 2025Article
- Development and evaluation of a clinical-biochemical nomogram for differentiating pleomorphic adenoma and Warthin's tumor in the parotid gland.Frontiers in oncology · 2025Article
- Clinical features and prognosis of carcinoma ex pleomorphic adenoma of the lacrimal gland: a comprehensive case series and literature review.International journal of ophthalmology · 2025Article
- Novel Detection of Pleomorphic Adenomas via Analysis ofCancers · 2024Article
- Long-term follow-up of tracheal pleomorphic adenoma: A case report.Respiratory medicine case reports · 2024Article
- An organoid library of salivary gland tumors reveals subtype-specific characteristics and biomarkers.Journal of experimental & clinical cancer research : CR · 2022Article
- Lip pleomorphic adenomas: case series and literature review.Gland surgery · 2022Article
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Authors and funding
6 authors.
Funding
Abstract
Background: Recurrence in pleomorphic adenoma (PA) has been debated as a risk factor for malignant transformation (MT). In this study, we investigated whether recurrence is a risk factor for MT, by longitudinally analyzing cases with recurrent PA (RPA), and carcinomas from PA (CXPA) or RPA (CXRPA). Methods: The study population included 24 CXPA, 24 RPA, 6 CXRPA, and 386 PA cases (study period 2010−2018). Time and event data were collected from the medical documents to identify the time−event sequences. Results: The time interval to MT in CXRPA was significant longer than that of benign recurrence (median 342.0 vs. 109.5 months). In CXRPA, the recurrence intervals were not shorter than those in RPA according to recurrence frequency. Crudely, the MT rate was 5.9% among primary cases and 20.0% among recurrent cases. However, the time-adjusted MT rates increased up to 11.4% (incubation time > 60 months) and 20.0% (>120 months) in primary cases, which were not different from recurrent cases. Conclusion: In these longitudinal analyses, we did not find any clinical evidence that recurrence facilitates MT in the background of PA. Instead, a long incubation time seems to be a key factor for MT of underlying RPA.
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