ReviewJournal of clinical medicine2022
Malignant Transformation Rate of Oral Submucous Fibrosis: A Systematic Review and Meta-Analysis.
Review in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review and meta-analysis of the impact of resveratrol on oral cancer: potential therapeutic implications.BMC oral health · 2024Pooled it
- From Chronic Inflammation to Malignancy: Molecular Mechanisms and Therapeutic Insights in Oral Carcinogenesis.International journal of molecular sciences · 2026Review
- Hypoxia and angiogenesis across clinical stages of oral submucous fibrosis: implications for oral carcinogenesis.BMC oral health · 2026Article
- Clinical and histopathological manifestations of snus use in Germany: parallels to betel nut-related oral submucous fibrosis in Asia.Virchows Archiv : an international journal of pathology · 2026Article
- Review
- Understanding betel nut addiction: a review of harmful consequences, underlying neurobiology, and emerging intervention strategies.Translational psychiatry · 2026Review
- Reactive Palatal Fibrosis Following Facial Dermal Filler Injection and Anfiye Inhalation: A Case Mimicking OSMF.Clinical case reports · 2026Article
- The Clinicodemographic Features of Oral Squamous Cell Carcinoma: A Single-Centre Retrospective Study.International journal of dentistry · 2026Article
- A Novel Fibrosis-Integrated Nomogram for Predicting Survival in Oral Squamous Cell Carcinoma Patients with Oral Submucous Fibrosis: A Retrospective Cohort Study.Cancer management and research · 2026Article
- Article
- The Areca Nut and Oral Submucosal Fibrosis: A Narrative Review.Dentistry journal · 2025Review
- Correlation of Newly Added Dysplastic Features in the Latest WHO Diagnostic Criteria of Oral Epithelial Dysplasia with Malignant Transformation and Recurrence.Head and neck pathology · 2025Article
- Clinical and histological indicators for malignant transformation of oral submucous fibrosis: an analysis of cases from a tertiary care center.BMC oral health · 2025Article
- Correlation of clinical presentation with prognosis in oral squamous cell carcinoma associated with oral submucous fibrosis.BMC cancer · 2025Article
- Curcumin Alleviates Arecoline-induced Oral Submucous Fibrosis via the FOSL1/MAPK8 Axis.Cell biochemistry and biophysics · 2025Article
- Screening of oral potentially malignant disorders and oral cancer using deep learning models.Scientific reports · 2025Article
- Oral submucous fibrosis: pathogenesis and therapeutic approaches.International journal of oral science · 2025Review
- Oral submucosal fibrosis: a comprehensive review on pathogenesis, diagnosis, therapeutics and computational advances.Frontiers in cell and developmental biology · 2025Review
- Multi-Omics Meets Premalignancy: Paving the Way for Early Prevention of Cancer.Research (Washington, D.C.) · 2025Review
- Role of optical imaging in oral cancer and oral potentially malignant disorders: implications for oral submucous fibrosis.Frontiers in oral health · 2025Review
Corrections and comments
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Authors and funding
21 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral submucous fibrosis (OSF) is a chronic progressive condition affecting the oral cavity, oropharynx and upper third of the oesophagus. It is a potentially malignant disorder. The authors collated and analysed the existing literature to establish the overall malignant transformation rate (MTR). A retrospective analysis of medical and dental scientific literature using online indexed databases was conducted for the period 1956 to 2021. The quality of the enrolled studies was assessed by the Newcastle-Ottawa Scale (NOS). A meta-analysis using a random effects model of a single proportion was performed along with statistical tests for heterogeneity. The overall proportion of malignancy across all studies was 0.06 (95% CI, 0.02-0.10), indicating an overall 6% risk of malignant transformation across all studies and cohorts. Sub-group analyses revealed strong differences in proportion of malignancy according to ethnicity/cohort; Chinese = 0.02 (95% CI 0.01-0.02), Taiwanese = 0.06 (95% CI, 0.03-0.10), Indian = 0.08 (95% CI, 0.03-0.14) and Pakistani = 0.27 (95% CI 0.25-0.29). Overall, the MTR was 6%; however, wide heterogeneity of the included studies was noted. Geographic variations in MTR were noted but were not statistically significant. Further studies are required to analyse the difference between cohort groups.
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