ArticleJournal of clinical medicine2022
Aberrant Structural Connectivity of the Triple Network System in Borderline Personality Disorder Is Associated with Behavioral Dysregulation.
Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Assessment of neurotransmitter-related structural brain changes in borderline personality disorder: an MRI study.Scientific reports · 2026Article
- Aberrant Salience Network Functional Connectivity in Resting-State and Fear-Related Autobiographical Memory Recall in Female Adolescents with Borderline Personality Disorder.Brain sciences · 2025Article
- Salience and default networks predict borderline personality traits and affective symptoms: a dynamic functional connectivity analysis.Frontiers in human neuroscience · 2025Article
- Diffusion-Weighted Magnetic Resonance Imaging: Clinical Potential and Applications.Journal of clinical medicine · 2022Article
- Structural white matter alterations in borderline personality disorder: A narrative review and methodological considerations.Science progressReview
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundCore symptoms of Borderline Personality Disorder (BPD) are associated to aberrant connectivity of the triple network system (salience network [SN], default mode network [DMN], executive control network [ECN]). While functional abnormalities are widely reported, structural connectivity (SC) and anatomical changes have not yet been investigated. Here, we explored the triple network's SC, structure, and its association with BPD clinical features.
methodsA total of 60 BPD and 26 healthy controls (HC) underwent a multidomain neuropsychological and multimodal MRI (diffusion- and T1-weighted imaging) assessment. Metrics (fractional anisotropy [FA], mean diffusivity [MD], cortical thickness) were extracted from SN, DMN, ECN (triple network), and visual network (control network) using established atlases. Multivariate general linear models were conducted to assess group differences in metrics and associations with clinical features.
resultsPatients showed increased MD in the anterior SN, dorsal DMN, and right ECN compared to HC. Diffusivity increases were more pronounced in patients with higher behavioral dysregulation, i.e., suicidal attempting, self-harm, and aggressiveness. No differences were detected in network structure.
conclusionsThese results indicate that the triple network system is impaired in BPD at the microstructural level. The preferential involvement of anterior and right-lateralized subsystems and their clinical association suggests that these abnormalities could contribute to behavioral dysregulation.
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