Evidence map›Paper›PMID 35407269›Full record

ArticleNanomaterials (Basel, Switzerland)2022

Aspartic Acid Stabilized Iron Oxide Nanoparticles for Biomedical Applications.

Mihaela Răcuciu, Lucian Barbu-Tudoran, Simona Oancea, Olga Drăghici, Cezarina Morosanu, Marian Grigoras, Florin Brînză, Dorina E Creangă

Abstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Amino acid-modified nano-magnetite boosts okra [Abelmoschus esculentus (L.) Moench] yield and iron enrichment for improved nutrition.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025
    Article
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  3. Critical Evaluation of Combined Cu and FeInternational journal of nanomedicine · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mihaela RăcuciuEnvironmental Sciences and Physics Department, Faculty of Sciences, "Lucian Blaga" University of Sibiu, Dr. I. Ratiu Str., no. 5-7, 550012 Sibiu, Romania.ORCID 0000-0002-4288-0144
Lucian Barbu-TudoranElectron Microscopy Integrated Laboratory, National Institute for R&D of Isotopic and Molecular Technologies, Donat Str., no. 67-103, 400293 Cluj-Napoca, Romania.
Simona OanceaAgricultural Sciences and Food Engineering Department, Lucian Blaga University of Sibiu, Dr. I. Ratiu Str., no. 7-9, 550012 Sibiu, Romania.ORCID 0000-0003-3832-6041
Olga DrăghiciAgricultural Sciences and Food Engineering Department, Lucian Blaga University of Sibiu, Dr. I. Ratiu Str., no. 7-9, 550012 Sibiu, Romania.ORCID 0000-0003-3702-5888
Cezarina MorosanuBiophysics and Medical Physics Laboratory, Faculty of Physics, "Alexandru Ioan Cuza" University, 11, Carol I Blvd., 700506 Iasi, Romania.
Marian GrigorasNational Institute of Research and Development for Technical Physics, 47, Mangeron Blvd., 700050 Iasi, Romania.ORCID 0000-0002-5618-1192
Florin BrînzăBiophysics and Medical Physics Laboratory, Faculty of Physics, "Alexandru Ioan Cuza" University, 11, Carol I Blvd., 700506 Iasi, Romania.
Dorina E CreangăBiophysics and Medical Physics Laboratory, Faculty of Physics, "Alexandru Ioan Cuza" University, 11, Carol I Blvd., 700506 Iasi, Romania.

Funding

JINR-RO cooperation project 04-4-1121-2015/2020 No 34- 2020Lucian Blaga University of Sibiu & Hasso Plattner Foundation research grants LBUS-IRG-2020-06
6 · The paper itself

Abstract

Aspartic acid stabilized iron oxide nanoparticles (A-IONPs) with globular shape and narrow size distribution were prepared by the co-precipitation method in aqueous medium. A quantum-mechanical approach to aspartic acid optimized structure displayed negative charged sites, relatively high dipole moment, and hydrophilicity, which recommended it for interaction with iron cations and surrounding water electrical dipoles. A-IONPs were characterized by TEM, XRD, ATR-FTIR, EDS, DSC, TG, DLS, NTA, and VSM techniques. Theoretical study carried out by applying Hartree-Fock and density functional algorithms suggested that some aspartic acid properties related to the interaction can develop with nanoparticles and water molecules. The results of experimental investigation showed that the mean value of particle physical diameters was 9.17 ± 2.2 nm according to TEM image analysis, the crystallite size was about 8.9 nm according to XRD data, while the magnetic diameter was about 8.8 nm, as was determined from VSM data interpretation with Langevin's theory. The A-IONP suspension was characterized by zeta-potential of about -11.7 mV, while the NTA investigation revealed a hydrodynamic diameter of 153.9 nm. These results recommend the A-IONP suspension for biomedical applications.

Indexed as

iron oxide nanoparticlesL-aspartic acidnanoparticles sizenanoparticles synthesisphysical and chemical characterization

Identifiers

PMID35407269
PMCPMC9000734

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.