Green Extraction-Assisted Pseudo-Targeted Profile of Alkaloids in Lotus Seed Epicarp Based on UPLC-QTOF MS with IDA.

Xiaoji Cao, Xupin Lin, Congcong Wu, Minghua Zhang, Mingwei Wang

Open access · goldAbstract read

In one paragraph

Article in Foods (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.9field-weighted citation impact, top 32% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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1 citing paper in PubMed, 10 citations in OpenAlex.

Therapeutic potential of Echinocactus grusonii and its associated endophytic fungus Aspergillus oryzae in neuroprotection: in vitro and in silico investigations.Scientific reports · 2026
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5 · Who and what money

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5 authors at 1 institution in 1 country.

Xiaoji CaoResearch Center of Analysis and Measurement, Zhejiang University of Technology, Hangzhou 310014, China.

Xupin LinCollege of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.

Congcong WuCollege of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.

Minghua ZhangCollege of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.

Mingwei WangCollege of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.

Zhejiang University of Technology · CN

Funding

National Natural Science Foundation of China No.21602200

6 · The paper itself

Abstract

Lotus seed epicarp, a byproduct of lotus, is commonly discarded directly or burned in the cropland, resulting in waste of resources and environmental pollution. In this work, a green ultrasonic-assisted extraction method with ethyl lactate as the extraction solvent was established to extract alkaloids from lotus seed epicarp. The extraction conditions were optimized by response surface methodology. Under the optimal extraction conditions, the extraction of alkaloids from 1 g lotus seed epicarp was accomplished with only 10 mL of extraction solvent within 15 min. Combined with ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry with information-dependent acquisition mode, a total of 42 alkaloids were annotated in the lotus seed epicarp extracts. Among them, 39 alkaloids were reported in lotus seed epicarp for the first time. According to quantitative analysis, the distributions and trends of alkaloids in the lotus seed epicarp were found to be similar to those of lotus leaves. The five growth stages of lotus seed epicarp could be successfully distinguished based on the ten representative alkaloids. This study demonstrates that ultrasonic-assisted extraction with ethyl lactate as extractant solvent was efficient in the extraction of alkaloids from lotus seed epicarp, which is a potential renewable resource of bioactive ingredients.

Indexed as

alkaloidsbio-based solventslotus seed epicarppseudo-targeted profileUPLC-QTOF MS

Identifiers

PMID35407146

DOI10.3390/foods11071056

PMCPMC8997499

OpenAlexW4223561916

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LicenceCC BY

Read underepoch 390

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.