ReviewPlants (Basel, Switzerland)2022
Biochemistry and Molecular Basis of Intracellular Flavonoid Transport in Plants.
Review in Plants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Natural products modulate renal metabolic reprogramming in diabetic kidney disease.Journal of translational internal medicine · 2026Article
- Progressive salinity drives flavonoid branch reprogramming in Anoectochilus roxburghii.BMC plant biology · 2026Article
- Anthocyanin accumulation in fruit crops: a multi-layered regulatory network integrating molecular, epigenetic, hormonal and environmental regulation.Molecular biology reports · 2026Review
- Genome-wide characterization of the glutathione S-transferase gene family identifies GmGSTF8 and GmGSTF11 as anthocyanin-associated GSTs in soybean.BMC plant biology · 2026Article
- Molecular Cloning, Biochemical Characterization, and Structural Insights into a Flavonoid-Associated Class II 4-Coumarate:CoA Ligase fromJournal of microbiology and biotechnology · 2026Article
- The Genome-Wide Identification of the GST Gene Family and Functional Characterization ofBiology · 2026Article
- Integrated metabolomics and transcriptomics analysis of flavonoids in different parts of Houttuynia cordata.BMC genomics · 2026Article
- Genome sequence of the ornamental plant Digitalis purpurea reveals the molecular basis of flower color and morphology variation.BMC genomics · 2026Article
- The Phenylpropanoid Pathway Is a Central Roundabout in Peach Fruit Pre- and Postharvest Physiology.Metabolites · 2026Article
- The vacuolar transporters MaMATE11 and MaMATE14 affect blue flower coloration in grape hyacinth (Horticulture research · 2026Article
- Chlorophyll depletion and anthocyanin compositional shifts distinguish spotted leaf sectors inFrontiers in plant science · 2026Article
- A tomato MAGIC population reveals candidate genes for leaf dry matter and phenolics, two key traits for stress resilience and climate-smart breeding.Frontiers in plant science · 2026Article
- Article
- Diversity and ecological functions of anthocyanins.BMC plant biology · 2025Review
- Tomato pollen tube growth requires flavonol glycosylation.Plant physiology · 2025Article
- Article
- Efficient, cell-type-specific production of flavonols by multiplexed CRISPR activation of a suite of metabolic enzymes.Nature communications · 2025Article
- Genome-Wide Transcriptome Analysis Reveals GRF Transcription Factors Involved in Methyl Jasmonate-Induced Flavonoid Biosynthesis inPlants (Basel, Switzerland) · 2025Article
- The Light-RegulatedInternational journal of molecular sciences · 2025Article
- Biosynthesis and Physiological Significance of Organ-Specific Flavonol Glycosides in Solanaceae.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Flavonoids are a biochemically diverse group of specialized metabolites in plants that are derived from phenylalanine. While the biosynthesis of the flavonoid aglycone is highly conserved across species and well characterized, numerous species-specific decoration steps and their relevance remained largely unexplored. The flavonoid biosynthesis takes place at the cytosolic side of the endoplasmatic reticulum (ER), but accumulation of various flavonoids was observed in the central vacuole. A universal explanation for the subcellular transport of flavonoids has eluded researchers for decades. Current knowledge suggests that a glutathione S-transferase-like protein (ligandin) protects anthocyanins and potentially proanthocyanidin precursors during the transport to the central vacuole. ABCC transporters and to a lower extend MATE transporters sequester anthocyanins into the vacuole. Glycosides of specific proanthocyanidin precursors are sequestered through MATE transporters. A P-ATPase in the tonoplast and potentially other proteins generate the proton gradient that is required for the MATE-mediated antiport. Vesicle-mediated transport of flavonoids from the ER to the vacuole is considered as an alternative or additional route.
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