Evidence map›Paper›PMID 35406786›Full record

ArticleCells2022

Comprehensive Analysis of CDK1-Associated ceRNA Network Revealing the Key Pathways LINC00460/LINC00525-Hsa-Mir-338-FAM111/ZWINT as Prognostic Biomarkers in Lung Adenocarcinoma Combined with Experiments.

Wen Li, Shan-Shan Feng, Hao Wu, Jing Deng, Wang-Yan Zhou, Ming-Xi Jia, Yi Shi, Liang Ma, Xiao-Xi Zeng, Zavuga Zuberi and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Wen LiCollege of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou 412007, China.
Shan-Shan FengCollege of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou 412007, China.
Hao WuNational Engineering Research Center of Rice and Byproduct Deep Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, China.
Jing DengCollege of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou 412007, China.
Wang-Yan ZhouDepartment of Medical Record, Hengyang Medical School, The First Affiliated Hospital, University of South China, Hengyang 421001, China.
Ming-Xi JiaNational Engineering Research Center of Rice and Byproduct Deep Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, China.
Yi ShiNational Engineering Research Center of Rice and Byproduct Deep Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, China.
Liang MaCollege of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou 412007, China.
Xiao-Xi ZengCollege of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou 412007, China.
Zavuga ZuberiDepartment of Science and Laboratory Technology, Dar es Salaam Institute of Technology, Dar es Salaam P.O. Box 2958, Tanzania.ORCID 0000-0003-0150-2005
Da FuCentral Laboratory for Medical Research, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.ORCID 0000-0002-0878-2575
Xiang LiuDepartment of Thoracic Surgery, Hengyang Medical School, The Second Affiliated Hospital, University of South China, Hengyang 421001, China.
Zhu ChenCollege of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou 412007, China.
Hunan University of Technology · CNCentral South University of Forestry and Technology · CNUniversity of South China · CNDar es Salaam Institute of Technology · TZTongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung adenocarcinoma (LUAD) is the leading cause of cancer deaths worldwide, and effective biomarkers are still lacking for early detection and prognosis prediction. Here, based on gene expression profiles of LUAD patients from The Cancer Genome Atlas (TCGA), 806 long non-coding RNAs (lncRNAs), 122 microRNAs (miRNAs) and 1269 mRNAs associated with CDK1 were identified. The regulatory axis of LINC00460/LINC00525-hsa-mir-338-FAM111B/ZWINT was determined according to the correlation between gene expression and patient prognosis. The abnormal up-regulation of FAM111B/ZWINT in LUAD was related to hypomethylation. Furthermore, immune infiltration analysis suggested FAM111B/ZWINT could affect the development and prognosis of cancer by regulating the LUAD immune microenvironment. EMT feature analysis suggested that FAM111B/ZWINT promoted tumor spread through the EMT process. Functional analysis showed FAM111B/ZWINT was involved in cell cycle events such as DNA replication and chromosome separation. We analyzed the HERB and GSCALite databases to identify potential target medicines that may play a role in the treatment of LUAD. Finally, the expression of LINC00460/LINC00525-hsa-mir-338-FAM111B/ZWINT axis was verified in LUAD cells by RT-qPCR, and these results were consistent with bioinformatics analysis. Overall, we constructed a CDK1-related ceRNA network and revealed the LINC00460/LINC00525-hsa-mir-338-FAM111/ZWINT pathways as potential diagnostic biomarkers or therapeutic targets of LUAD.

Indexed as

AdenocarcinomaLung NeoplasmsMicroRNAsBiomarkers, TumorCDC2 Protein KinaseCell Cycle ProteinsGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansIntracellular Signaling Peptides and ProteinsLungNuclear ProteinsPrognosisTumor MicroenvironmentBiomarkers, TumorCDC2 Protein KinaseCDK1 protein, humanCell Cycle ProteinsFAM111B protein, humanIntracellular Signaling Peptides and ProteinsMicroRNAsMIRN338 microRNA, humanNuclear ProteinsZWINT protein, humanCDK1 geneceRNA networkFAM111B/ZWINT geneLINC00525/LINC00460Lung adenocarcinomaprognosis

Identifiers

PMID35406786
PMCPMC8997540
OpenAlexW4223638749

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.