Evidence map›Paper›PMID 35406639›Full record

ReviewCells2022

Progesterone and Inflammatory Response in the Oviduct during Physiological and Pathological Conditions.

Emily A McGlade, Akio Miyamoto, Wipawee Winuthayanon

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Study Models forMicroorganisms · 2025
    Review
  8. Review
  9. Article
  10. Biofilm · 2024
    Review
  11. Anti‑inflammatory effects of methanol extract fromExperimental and therapeutic medicine · 2024
    Article
  12. PAQR4 oncogene: a novel target for cancer therapy.Medical oncology (Northwood, London, England) · 2024
    Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Gender-Specific Impact of Sex Hormones on the Immune System.International journal of molecular sciences · 2023
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Emily A McGladeCenter for Reproductive Biology, School of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA.ORCID 0000-0003-4979-9979
Akio MiyamotoGlobal Agromedicine Research Center (GAMRC), Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080-8555, Japan.
Wipawee WinuthayanonCenter for Reproductive Biology, School of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA.ORCID 0000-0002-5196-8471
Washington State University · USObihiro University of Agriculture and Veterinary Medicine · JP

Funding

The actions of steroid hormones on oviduct functionR01HD097087 · NICHD · WASHINGTON STATE UNIVERSITY · PI WINUTHAYANON, WIPAWEE · 2019 to 2023
$1.7M
The Role of Progesterone Receptor in the Oviduct Epithelium for Pregnancy EstablishmentF31HD107807 · NICHD · WASHINGTON STATE UNIVERSITY · PI MCGLADE, EMILY A · 2021 to 2021
$28k
NICHD NIH HHS F31 HD107807
6 · The paper itself

Abstract

Progesterone has been shown to be a potent suppressor of several inflammatory pathways. During pregnancy, progesterone levels increase, allowing for normal pregnancy establishment and maintenance. The dysregulation of progesterone, as well as inflammation, leads to poor pregnancy outcomes. However, it is unclear how progesterone imbalance could impact inflammatory responses in the oviduct and subsequently result in early pregnancy loss. Therefore, in this review, we describe the role of progesterone signaling in regulating the inflammatory response, with a focus on the oviduct and pathological conditions in the Fallopian tubes.

Indexed as

Fallopian TubesProgesteroneAnimalsFemaleHumansOviductsPregnancyReceptors, ProgesteroneProgesteroneReceptors, Progesteronecytokinesepitheliuminflammationinterleukinsoviductpregnancyprogesteronetoll-like receptor

Identifiers

PMID35406639
PMCPMC8997425
OpenAlexW4220709988

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.