Evidence map›Paper›PMID 35406546›Full record

ArticleCancers2022

Radiation Dose of Contrast-Enhanced Mammography: A Two-Center Prospective Comparison.

Gisella Gennaro, Andrea Cozzi, Simone Schiaffino, Francesco Sardanelli, Francesca Caumo

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Contrast-enhanced mammography improves patient access to functional breast imaging.Journal of medical imaging and radiation oncology · 2025
    Review
  10. Contrast-enhanced mammography in high-dense breasts: a narrative review.Translational breast cancer research : a journal focusing on translational research in breast cancer · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. State-of-the-art for contrast-enhanced mammography.The British journal of radiology · 2024
    Review
  15. Article
  16. Article
  17. Contrast-enhanced mammography-guided biopsy: technique and initial outcomes.Quantitative imaging in medicine and surgery · 2023
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Gisella GennaroUnit of Breast Radiology, Veneto Institute of Oncology (IOV) IRCCS, Via Gattamelata 64, 35128 Padua, Italy.ORCID 0000-0003-2444-1778
Andrea CozziDepartment of Biomedical Sciences for Health, Università degli Studi di Milano, Via Mangiagalli 31, 20133 Milano, Italy.ORCID 0000-0003-4922-7065
Simone SchiaffinoUnit of Radiology, IRCCS Policlinico San Donato, Via Morandi 30, 20097 San Donato Milanese, Italy.ORCID 0000-0003-4243-888X
Francesco SardanelliDepartment of Biomedical Sciences for Health, Università degli Studi di Milano, Via Mangiagalli 31, 20133 Milano, Italy.ORCID 0000-0001-6545-9427
Francesca CaumoUnit of Breast Radiology, Veneto Institute of Oncology (IOV) IRCCS, Via Gattamelata 64, 35128 Padua, Italy.
Istituto Oncologico Veneto · ITUniversity of Milan · ITIRCCS Policlinico San Donato · IT

Funding

Regione del Veneto RSF-2017-00000562
6 · The paper itself

Abstract

The radiation dose associated with contrast-enhanced mammography (CEM) has been investigated only by single-center studies. In this retrospective study, we aimed to compare the radiation dose between two centers performing CEM within two prospective studies, using the same type of equipment. The CEM mean glandular dose (MGD) was computed for low energy (LE) and high energy (HE) images and their sum was calculated for each view. MGD and related parameters (entrance dose, breast thickness, compression, and density) were compared between the two centers using the Mann−Whitney test. Finally, per-patient MGD was calculated by pooling the two datasets and determining the contribution of LE and HE images. A total of 348 CEM examinations were analyzed (228 from Center 1 and 120 from Center 2). The median total MGD per view was 2.33 mGy (interquartile range 2.19−2.51 mGy) at Center 1 and 2.46 mGy (interquartile range 2.32−2.70 mGy) at Center 2, with a 0.15 mGy median difference (p < 0.001) equal to 6.2%. LE-images contributed between 64% and 77% to the total patient dose in CEM, with the remaining 23−36% being associated with HE images. The mean radiation dose for a two-view bilateral CEM exam was 4.90 mGy, about 30% higher than for digital mammography.

Indexed as

breast cancercontrast-enhanced mammographyradiation dose

Identifiers

PMID35406546
PMCPMC8997084
OpenAlexW4220665945

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.