Evidence map›Paper›PMID 35406502›Full record

ArticleCancers2022

Endoscopic Ultrasound Plus Endoscopic Retrograde Cholangiopancreatography Based Tissue Sampling for Diagnosis of Proximal and Distal Biliary Stenosis Due to Cholangiocarcinoma: Results from a Retrospective Single-Center Study.

Edoardo Troncone, Fabio Gadaleta, Omero Alessandro Paoluzi, Cristina Maria Gesuale, Vincenzo Formica, Cristina Morelli, Mario Roselli, Luca Savino, Giampiero Palmieri, Giovanni Monteleone and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Endoscopic management of primary sclerosing cholangitis.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Edoardo TronconeGastroenterology Unit, Department of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Fabio GadaletaGastroenterology Unit, Department of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Omero Alessandro PaoluziGastroenterology Unit, Department of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Cristina Maria GesualeGastroenterology Unit, Department of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Vincenzo FormicaMedical Oncology Unit, Department of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.ORCID 0000-0002-5380-3144
Cristina MorelliMedical Oncology Unit, Department of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Mario RoselliMedical Oncology Unit, Department of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Luca SavinoPathology Unit, Department of Biomedicine and Prevention, University of Rome "Tor Vergata", 00133 Rome, Italy.ORCID 0000-0001-9068-2225
Giampiero PalmieriPathology Unit, Department of Biomedicine and Prevention, University of Rome "Tor Vergata", 00133 Rome, Italy.ORCID 0000-0003-4588-0219
Giovanni MonteleoneGastroenterology Unit, Department of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.ORCID 0000-0003-1339-9076
Giovanna Del Vecchio BlancoGastroenterology Unit, Department of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.ORCID 0000-0002-6327-563X
University of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Differentiating between benign and malignant biliary stenosis (BS) is challenging, where tissue diagnosis plays a crucial role. Endoscopic retrograde cholangiopancreatography (ERCP)-based tissue sampling and endoscopic ultrasound (EUS) with fine-needle aspiration (FNA) or biopsy (FNB) are used to obtain tissue specimens from BS. The aim of this retrospective study was to evaluate the diagnostic yield of EUS-FNA/B plus ERCP with brushing or forceps biopsy in BS. All endoscopic procedures performed in patients with BS at our gastroenterology unit were reviewed. The gold standard for diagnosis was histopathology of surgical specimens or the progression of the malignancy at radiological or clinical follow-up. A total of 70 endoscopic procedures were performed in 51 patients with BS. Final endoscopic diagnosis was reached in 96% of the patients and was malignant in 61.7% and benign in 38.3% of cases. Sensitivity, specificity, and diagnostic accuracy were 73.9%, 100%, and 80%, respectively, for EUS-FNA/B; 66.7%, 100%, and 82.5% for ERCP; and 83.3%, 100%, and 87.5% for both procedures carried out in the same session. The combination of EUS and ERCP tissue sampling seems to increase diagnostic accuracy in defining the etiology of BS. Performing both procedures in a single session reduces the time required for diagnostic work-up and optimizes resources.

Indexed as

biliary neoplasiabrushing cytologycholangiocarcinomaERCPEUS-FNB

Identifiers

PMID35406502
PMCPMC8997048
OpenAlexW4220697668

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.