Evidence map›Paper›PMID 35406499›Full record

ArticleCancers2022

Multiparametric

Lale Umutlu, Julian Kirchner, Nils-Martin Bruckmann, Janna Morawitz, Gerald Antoch, Saskia Ting, Ann-Kathrin Bittner, Oliver Hoffmann, Lena Häberle, Eugen Ruckhäberle and 9 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. The role ofRadiation oncology (London, England) · 2024
    Pooled it
  3. Pooled it
  4. [Breast (Edinburgh, Scotland) · 2026
    Trial
  5. Breast cancer research : BCR · 2025
    Trial
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. La Radiologia medica · 2025
    Article
  12. AI Applications to Breast MRI: Today and Tomorrow.Journal of magnetic resonance imaging : JMRI · 2024
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Radiomics based onFrontiers in oncology · 2024
    Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 2 countries.

Lale UmutluDepartment of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.
Julian KirchnerDepartment of Diagnostic and Interventional Radiology, University Dusseldorf, Medical Faculty, 40225 Dusseldorf, Germany.
Nils-Martin BruckmannDepartment of Diagnostic and Interventional Radiology, University Dusseldorf, Medical Faculty, 40225 Dusseldorf, Germany.
Janna MorawitzDepartment of Diagnostic and Interventional Radiology, University Dusseldorf, Medical Faculty, 40225 Dusseldorf, Germany.
Gerald AntochDepartment of Diagnostic and Interventional Radiology, University Dusseldorf, Medical Faculty, 40225 Dusseldorf, Germany.
Saskia TingInstitute of Pathology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen and the German Cancer Consortium (DKTK), 45147 Essen, Germany.
Ann-Kathrin BittnerDepartment Gynecology and Obstetrics, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.
Oliver HoffmannDepartment Gynecology and Obstetrics, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.
Lena HäberleInstitute of Pathology, Medical Faculty, Heinrich-Heine-University and University Hospital Duesseldorf, 40225 Duesseldorf, Germany.ORCID 0000-0002-8793-568X
Eugen RuckhäberleDepartment of Gynecology, University Dusseldorf, Medical Faculty, 40225 Dusseldorf, Germany.
Onofrio Antonio CatalanoDivision of Abdominal Radiology, Massachusetts General Hospital, Boston, MA 02129, USA.ORCID 0000-0001-7733-4138
Michal ChodylaDepartment of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.
Johannes GrueneisenDepartment of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.
Harald H QuickErwin L. Hahn Institute for Magnetic Resonance Imaging, University of Duisburg-Essen, 45141 Essen, Germany.
Wolfgang P FendlerDepartment of Nuclear Medicine, University of Duisburg-Essen and German Cancer Consortium (DKTK)-University Hospital Essen, 45147 Essen, Germany.
Christoph RischplerDepartment of Nuclear Medicine, University of Duisburg-Essen and German Cancer Consortium (DKTK)-University Hospital Essen, 45147 Essen, Germany.
Ken HerrmannDepartment of Nuclear Medicine, University of Duisburg-Essen and German Cancer Consortium (DKTK)-University Hospital Essen, 45147 Essen, Germany.
Peter GibbsDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Katja PinkerDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0002-2722-7331
Deutschen Konsortium für Translationale Krebsforschung · DEHeinrich Heine University Düsseldorf · DEUniversity of Duisburg-Essen · DEMemorial Sloan Kettering Cancer Center · USDüsseldorf University Hospital · DEErwin L. Hahn Institute for Magnetic Resonance Imaging · DEMassachusetts General Hospital · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Deutsche Forschungsgemeinschaft BU3075/2-1 & KI2434/1-2NCI NIH HHS P30 CA008748NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundThe aim of this study was to assess whether multiparametric

methodsA total of 73 female patients (mean age 49 years; range 27-77 years) with newly diagnosed, therapy-naive breast cancer underwent simultaneous

resultsThe best results in terms of AUCs and NPV for predicting complete pathological response in the entire cohort were obtained by the combination of all MR sequences and PET (0.8 and 79.5%, respectively), and no significant differences from the other models were observed. In further subgroup analyses, combining all MR and PET data, the best AUC (0.94) for predicting complete pathologic response was obtained in the HR+/HER2- group. No difference between results with/without the inclusion of PET characteristics was observed in the TN/HER2+ group, each leading to an AUC of 0.92 for all MR and all MR + PET datasets.

conclusion

Indexed as

breast cancermultiparametric 18F-FDG PET/MRIradiomicsradiomics-based prediction of pathologic complete response

Identifiers

PMID35406499
PMCPMC8996836
OpenAlexW4220909654

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.