ReviewCancers2022
Pneumatosis Intestinalis Induced by Anticancer Treatment: A Systematic Review.
Review in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- Erlotinib-Induced Pneumatosis Intestinalis: A Case Report and Review of Literature.Respirology case reports · 2026Article
- Pneumatosis intestinalis revisited: associated imaging findings, clinical correlation, management, risk stratification and future perspectives.Emergency radiology · 2026Review
- The Clinical Effect of Endoscopic Mucosal Needle Aspiration Combined with Anhydrous Alcohol in the Treatment of Pneumatosis Cystoides Intestinalis.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2026Article
- Two patients with pneumatosis intestinalis with distinct risk profiles managed conservatively.World journal of emergency medicine · 2026Article
- Multi-slice computed tomography diagnosis of pneumatosis cystoides intestinalis with pneumoperitoneum in high-altitude regions: preventing unnecessary laparotomies.Quantitative imaging in medicine and surgery · 2026Article
- Pneumatosis cystoides intestinalis with colonic perforation: A case report and literature review.Medicine · 2025Review
- Case Report: A case of melanosis coli complicated by pneumatosis intestinalis-induced volvulus.Frontiers in medicine · 2025Article
- Pneumatosis Cystoides Intestinalis Which Developed During Treatment forACG case reports journal · 2024Article
- 5-Fluorouracil-Related Pneumatosis Intestinalis: A Case Report and Review of the Literature.Cureus · 2024Article
- Article
- Chemotherapy-induced pneumatosis intestinalis followed by hepatic portal venous gas. A case report.The Journal of international medical research · 2024Article
- Imaging diagnosis of a rare case of intermittent intestinal pneumatosis: A consequence of ileocecal valve clip dysfunction?Radiology case reports · 2024Article
- Pneumatosis intestinalis in cancer patients who received immune checkpoint inhibitors.Journal of cancer research and clinical oncology · 2023Article
- Surgical complications of oncological treatments: A narrative review.World journal of gastrointestinal surgery · 2023Review
- The spectrum of pneumatosis intestinalis in the adult. A surgical dilemma.World journal of gastrointestinal surgery · 2023Review
- Pneumatosis cystoides intestinalis in dermatomyositis: a case series report and literature review.Frontiers in immunology · 2023Review
- Pneumatosis intestinalis post steroid use in a patient with immune-related adverse events: Case report, literature review and FAERS analysis.Frontiers in pharmacology · 2023Article
- Pneumatosis Intestinalis Induced by Alpha-Glucosidase Inhibitors in Patients with Diabetes Mellitus.Journal of clinical medicine · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pneumatosis intestinalis (PI) is a rare condition due to the presence of gas within the bowel wall; it is mainly caused by endoscopic procedures, infections and other gastrointestinal diseases. Oncological therapies have been reported to be a cause of PI as well, but their role is not clearly defined. This systematic review investigates the concurrency of PI and antitumor therapy in cancer patients, considering both solid tumors and onco-hematological ones. We performed a literature review of PubMed, Embase and the Web of Science up to September 2021 according to the PRISMA guidelines. A total of 62 papers reporting 88 different episodes were included. PI was mainly reported with targeted therapies (sunitinib and bevacizumab above all) within the first 12 weeks of treatment. This adverse event mostly occurred in the metastatic setting, but in 10 cases, it also occurred also in the neoadjuvant and adjuvant setting. PI was mostly localized in the large intestine, being fatal in 11 cases, while in the remaining cases, symptoms were usually mild, or even absent. A significant risk of PI reoccurrence after drug reintroduction was also reported (6/18 patients), with no fatal outcomes. Potential pharmacological mechanisms underlying PI pathogenesis are also discussed. In conclusion, although uncommonly, PI can occur during oncological therapies and may lead to life-threatening complications; therefore, consideration of its occurrence among other adverse events is warranted in the presence of clinical suspicion.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.