Evidence map›Paper›PMID 35406426›Full record

ReviewCancers2022

Using Quantitative Imaging for Personalized Medicine in Pancreatic Cancer: A Review of Radiomics and Deep Learning Applications.

Kiersten Preuss, Nate Thach, Xiaoying Liang, Michael Baine, Justin Chen, Chi Zhang, Huijing Du, Hongfeng Yu, Chi Lin, Michael A Hollingsworth and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.

  1. Artificial Intelligence in Pancreatic Imaging: A Systematic Review.United European gastroenterology journal · 2025
    Pooled it
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  20. Radiomics in glioma: emerging trends and challenges.Annals of clinical and translational neurology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Kiersten PreussDepartment of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Nate ThachDepartment of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Xiaoying LiangDepartment of Radiation Oncology, Mayo Clinic, Jacksonville, FL 32224, USA.
Michael BaineDepartment of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0002-1163-7539
Justin ChenDepartment of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Chi ZhangSchool of Biological Sciences, University of Nebraska Lincoln, Lincoln, NE 68588, USA.
Huijing DuDepartment of Mathematics, University of Nebraska Lincoln, Lincoln, NE 68588, USA.
Hongfeng YuDepartment of Computer Science, University of Nebraska Lincoln, Lincoln, NE 68588, USA.ORCID 0000-0002-0596-8227
Chi LinDepartment of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Michael A HollingsworthEppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Dandan ZhengDepartment of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0003-2259-1633
University of Nebraska–Lincoln · USUniversity of Nebraska Medical Center · USMayo Clinic in Florida · USNorth Central College · USUniversity of Rochester · US

Funding

Tissue CoreP50CA127297 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BATRA, SURINDER K. · 2008 to 2018
$17.1M
NIH HHS 2P50CA127297-06A1
6 · The paper itself

Abstract

As the most lethal major cancer, pancreatic cancer is a global healthcare challenge. Personalized medicine utilizing cutting-edge multi-omics data holds potential for major breakthroughs in tackling this critical problem. Radiomics and deep learning, two trendy quantitative imaging methods that take advantage of data science and modern medical imaging, have shown increasing promise in advancing the precision management of pancreatic cancer via diagnosing of precursor diseases, early detection, accurate diagnosis, and treatment personalization and optimization. Radiomics employs manually-crafted features, while deep learning applies computer-generated automatic features. These two methods aim to mine hidden information in medical images that is missed by conventional radiology and gain insights by systematically comparing the quantitative image information across different patients in order to characterize unique imaging phenotypes. Both methods have been studied and applied in various pancreatic cancer clinical applications. In this review, we begin with an introduction to the clinical problems and the technology. After providing technical overviews of the two methods, this review focuses on the current progress of clinical applications in precancerous lesion diagnosis, pancreatic cancer detection and diagnosis, prognosis prediction, treatment stratification, and radiogenomics. The limitations of current studies and methods are discussed, along with future directions. With better standardization and optimization of the workflow from image acquisition to analysis and with larger and especially prospective high-quality datasets, radiomics and deep learning methods could show real hope in the battle against pancreatic cancer through big data-based high-precision personalization.

Indexed as

deep learningmachine learningpancreatic cancerquantitative imagingradiomics

Identifiers

PMID35406426
PMCPMC8997008
OpenAlexW4220797967

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.