Evidence map›Paper›PMID 35406251›Full record

ArticlePolymers2022

DNA-Lysozyme Nanoarchitectonics: Quantitative Investigation on Charge Inversion and Compaction.

Rongyan Zhang, Yanwei Wang, Guangcan Yang

Open access · goldAbstract read
In one paragraph

Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Dynamic Light Scattering of DNA-Ligand Complexes.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  6. Encapsulation of Folic Acid andAntioxidants (Basel, Switzerland) · 2023
    Article
  7. DNA Penetration into a Lysozyme Layer at the Surface of Aqueous Solutions.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Rongyan ZhangDepartment of Physics, Wenzhou University, Wenzhou 325035, China.
Yanwei WangDepartment of Physics, Wenzhou University, Wenzhou 325035, China.
Guangcan YangDepartment of Physics, Wenzhou University, Wenzhou 325035, China.
Wenzhou University · CN

Funding

National Natural Science Foundation of China 12074289, 11574232
6 · The paper itself

Abstract

The interaction between DNA and proteins is fundamentally important not only for basic research in biology, but also for potential applications in nanotechnology. In the present study, the complexes formed by λ DNA and lysozyme in a dilute aqueous solution have been investigated using magnetic tweezers (MT), dynamic light scattering (DLS), and atomic force microscopy (AFM). We found that lysozyme induced DNA charge inversion by measuring its electrophoretic mobility by DLS. Lysozyme is very effective at neutralizing the positive charge of DNA, and its critical charge ration to induce charge inversion in solution is only 2.26. We infer that the high efficiency of charge neutralization is due to the highly positively charged (+8 e) and compact structure of lysozyme. When increasing the concentration of lysozymes from 6 ng·µL

Indexed as

condensing forcesDNA compactionlysozyme

Identifiers

PMID35406251
PMCPMC9002893
OpenAlexW4221112786

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.