Evidence map›Paper›PMID 35406143›Full record

ArticleNutrients2022

Sulfur Amino Acid Supplementation Abrogates Protective Effects of Caloric Restriction for Enhancing Bone Marrow Regrowth Following Ionizing Radiation.

Christopher Hine, J Humberto Treviño-Villarreal, Pedro Mejia, Alban Longchamp, Lear E Brace, Eylul Harputlugil, Sarah J Mitchell, Jie Yang, Yihong Guan, Jaroslaw P Maciejewski and 2 more

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Targeting macro- and micro-nutrient regulation of HNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  4. Research Progress on Dietary Intervention in Radiation Protection.Dose-response : a publication of International Hormesis Society
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Christopher HineDepartment of Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, USA.ORCID 0000-0003-1926-7939
J Humberto Treviño-VillarrealDepartment of Molecular Metabolism (Formally Genetics and Complex Diseases), Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Pedro MejiaDepartment of Molecular Metabolism (Formally Genetics and Complex Diseases), Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Alban LongchampDepartment of Molecular Metabolism (Formally Genetics and Complex Diseases), Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Lear E BraceDepartment of Molecular Metabolism (Formally Genetics and Complex Diseases), Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Eylul HarputlugilDepartment of Molecular Metabolism (Formally Genetics and Complex Diseases), Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Sarah J MitchellDepartment of Molecular Metabolism (Formally Genetics and Complex Diseases), Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Jie YangDepartment of Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, USA.ORCID 0000-0002-2102-3792
Yihong GuanDepartment of Translational Hematology & Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH 44195, USA.ORCID 0000-0001-8002-5141
Jaroslaw P MaciejewskiDepartment of Translational Hematology & Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Babal K JhaDepartment of Translational Hematology & Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH 44195, USA.ORCID 0000-0002-7660-5255
James R MitchellDepartment of Molecular Metabolism (Formally Genetics and Complex Diseases), Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Harvard University · USCleveland Clinic · USCleveland Clinic Lerner College of Medicine · US

Funding

Iron Catalyzed H2S and its Prevalence in Hemolytic and Iron Overload DisordersR01HL148352 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI HINE, CHRISTOPHER MICHAEL · 2019 to 2021
$964k
Requirement of hydrogen sulfide for the benefits of dietary sulfur amino acid restrictionR00AG050777 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI HINE, CHRISTOPHER MICHAEL · 2017 to 2019
$747k
NHLBI NIH HHS R01 HL148352NIA NIH HHS R00 AG050777NIH HHS AG050777NIH HHS HL148352
6 · The paper itself

Abstract

Radiation therapy damages and depletes total bone marrow (BM) cellularity, compromising safety and limiting effective dosing. Aging also strains total BM and BM hematopoietic stem and progenitor cell (HSPC) renewal and function, resulting in multi-system defects. Interventions that preserve BM and BM HSPC homeostasis thus have potential clinical significance. Here, we report that 50% calorie restriction (CR) for 7-days or fasting for 3-days prior to irradiation improved mouse BM regrowth in the days and weeks post irradiation. Specifically, one week of 50% CR ameliorated loss of total BM cellularity post irradiation compared to

Indexed as

Hydrogen SulfideRadiation InjuriesAnimalsBone MarrowCaloric RestrictionDietary SupplementsMethionineMiceMice, Inbred C57BLRadiation, IonizingHydrogen SulfideMethioninebone marrowcaloric restriction (CR)cystathionine γ-lyase (CGL)fastinghydrogen sulfide (H2S)radioprotection

Identifiers

PMID35406143
PMCPMC9002760
OpenAlexW4223502723

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.