Evidence map›Paper›PMID 35406139›Full record

Trial reportNutrients2022

Effect of Long-Term Hydroxytyrosol Administration on Body Weight, Fat Mass and Urine Metabolomics: A Randomized Double-Blind Prospective Human Study.

Christina Fytili, Theodora Nikou, Nikolaos Tentolouris, Ioulia K Tseti, Charilaos Dimosthenopoulos, Petros P Sfikakis, Dimitrios Simos, Alexandros Kokkinos, Alexios L Skaltsounis, Nikolaos Katsilambros and 1 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Christina FytiliFirst Department of Propaedeutic and Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, 17 Agiou Thoma Street, 11527 Athens, Greece.
Theodora NikouDepartment of Pharmacy, Division of Pharmacognosy and Natural Products Chemistry, National and Kapodistrian University of Athens, Panepistimioupoli Zografou, 11527 Athens, Greece.ORCID 0000-0001-5810-8602
Nikolaos TentolourisFirst Department of Propaedeutic and Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, 17 Agiou Thoma Street, 11527 Athens, Greece.ORCID 0000-0003-0615-2534
Ioulia K TsetiUni-Pharma SA, 14th klm National Road 1, Kifissia, 14564 Athens, Greece.
Charilaos DimosthenopoulosDepartment of Clinical Nutrition, Laiko General Hospital, 17 Agiou Thoma Street, 11527 Athens, Greece.
Petros P SfikakisFirst Department of Propaedeutic and Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, 17 Agiou Thoma Street, 11527 Athens, Greece.
Dimitrios SimosFirst Department of Propaedeutic and Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, 17 Agiou Thoma Street, 11527 Athens, Greece.ORCID 0000-0001-9138-3446
Alexandros KokkinosFirst Department of Propaedeutic and Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, 17 Agiou Thoma Street, 11527 Athens, Greece.
Alexios L SkaltsounisDepartment of Pharmacy, Division of Pharmacognosy and Natural Products Chemistry, National and Kapodistrian University of Athens, Panepistimioupoli Zografou, 11527 Athens, Greece.
Nikolaos KatsilambrosResearch Laboratory Christeas Hall, Medical School, National and Kapodistrian University of Athens, 15b Agiou Thoma Street, 11527 Athens, Greece.ORCID 0000-0001-6092-9493
Maria HalabalakiDepartment of Pharmacy, Division of Pharmacognosy and Natural Products Chemistry, National and Kapodistrian University of Athens, Panepistimioupoli Zografou, 11527 Athens, Greece.ORCID 0000-0001-5620-0165
National and Kapodistrian University of Athens · GRLaiko General Hospital of Athens · GRUni Pharma (Greece) · GR

Funding

European Union 5048539European Union Τ1ΕΔΚ-04267
6 · The paper itself

Abstract

Hydroxytyrosol (HT) is a natural antioxidant found in olive products and characterized by well-documented beneficial effects on human health. Several research studies are ongoing that aim to investigate its potency and molecular mechanism of action. The present study aimed to investigate the potential effect of HT on human obesity through a randomized double-blind prospective design. HT in two different doses (15 and 5 mg/day) and a placebo capsule was administered to 29 women with overweight/obesity for six months and their weight and fat mass were monitored at three time points (baseline, 4, 12 and 24 weeks). Statistically significant weight and visceral fat mass loss (%weight loss:

Indexed as

MetabolomicsOverweightBody WeightDouble-Blind MethodFemaleHumansObesityPhenylethyl AlcoholProspective Studies3,4-dihydroxyphenylethanolPhenylethyl Alcoholhuman cohorthydroxytyrosolmetabolomicsobesityUPLC-Orbitrap-MSweight and fat loss

Identifiers

PMID35406139
PMCPMC9003406
OpenAlexW4223453543

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.