ArticleNutrients2022
The Association between Lead Exposure and Bone Mineral Density in Childhood and Adolescence: Results from NHANES 1999-2006 and 2011-2018.
Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 28 citations in OpenAlex.
- Association Between Lead Exposure and Anthropometric Indicators in School-aged Children: A Longitudinal Study.Biological trace element research · 2026Article
- Blood heavy metal levels and bone turnover markers in Korean elementary school children.Central European journal of public health · 2026Article
- Baseline exposure-response assessment of metals from dried blood spots and personal household air pollution concentrations among pregnant women in Rwanda: household air pollution intervention network trial.Journal of health, population, and nutrition · 2025Article
- Association of triglycerides with bone mineral density in children and adolescents: a cross-sectional study.BMC musculoskeletal disorders · 2025Article
- Impact of Maternal Exposure to Trace Metal Mixtures on Bone Mineral Density in Children Aged 3-6: Results from the Guangxi Zhuang Birth Cohort, China.Biological trace element research · 2025Article
- Article
- Lead poisoning and its effects on bone density.Scientific reports · 2025Article
- Osteoclast-derived exosomal miR-30a-3p promotes lead exposure-induced osteoporosis by triggering osteoblastic pyroptosis.Clinical science (London, England : 1979) · 2025Article
- Association between cardiometabolic index and bone mineral density among adolescents in the United States.Frontiers in endocrinology · 2025Article
- Exposure to polycyclic aromatic hydrocarbons and bone mineral density in children and adolescents: results from the 2011-2016 National Health and Nutrition Examination Survey.Frontiers in public health · 2025Article
- The Association between Fluoride and Bone Mineral Density in US Children and Adolescents: A Pilot Study.Nutrients · 2024Article
- Article
- Association between composite dietary antioxidant and bone mineral density in children and adolescents aged 8-19 years: findings from NHANES.Scientific reports · 2024Article
- Opposing Effects of Nutritional Supply on Bone Health at Different Ages: Based on the National Health and Nutrition Examination Survey Database.Nutrients · 2024Article
- The Association between Serum Copper and Bone Mineral Density among Adolescents Aged 12 to 19 in the United States.Nutrients · 2024Article
- The influence of adult urine lead exposure on bone mineral densit: NHANES 2015-2018.Frontiers in endocrinology · 2024Article
- The different association between fat mass distribution and intake of three major nutrients in pre- and postmenopausal women.PloS one · 2024Article
- The Effects of Claw Health and Bone Mineral Density on Lameness in Duroc Boars.Animals : an open access journal from MDPI · 2023Article
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- Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
There are few studies on lead's effect on bone mineral density (BMD) in childhood. In this study, we examined the association between lead exposure and BMD among 13,951 children and adolescents aged 8-19 years from NHANES 1999-2006 and 2011-2018. The whole blood lead levels (BLLs) were used as lead exposure biomarkers, and total BMD, subtotal BMD, lumbar spine BMD and limb BMD were used as outcome variables. The survey weighted multivariable generalized additive models (GAMs) with smoothing terms were used to explore the association between blood lead levels and BMDs, adjusted for age, sex, race/ethnicity, height, weight, family-income-to-poverty ratio and blood cadmium. Subgroup analyses stratified by sex and bony sites were further performed. We found an N-shaped curve association between BLLs and total BMD, subtotal BMD and limb BMD for males and females, whereas the association between BLLs and lumbar spine BMD was only significantly negative for females. The findings suggested that lead exposure had different effects on BMD of different bony sites (highly cortical or trabecular regions) in childhood and adolescence and had different effects on the same bone among different ages population and/or at different levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.