Evidence map›Paper›PMID 35406111›Full record

ArticleNutrients2022

Evaluation of the Safety of a Plant-Based Infant Formula Containing Almonds and Buckwheat in a Neonatal Piglet Model.

Fernanda Rosa, Brooke Yelvington, Nathan Terry, Patricia Tripp, Hoy E Pittman, Bobby L Fay, Taylor J Ross, James D Sikes, Jessica B Flowers, Fabiana Bar-Yoseph and 1 more

Abstract read
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Fernanda RosaUnited States Department of Agriculture-Agriculture Resaarch Service, Arkansas Children's Nutrition Center, Little Rock, AR 72202, USA.ORCID 0000-0002-8906-4056
Brooke YelvingtonUnited States Department of Agriculture-Agriculture Resaarch Service, Arkansas Children's Nutrition Center, Little Rock, AR 72202, USA.
Nathan TerryUnited States Department of Agriculture-Agriculture Resaarch Service, Arkansas Children's Nutrition Center, Little Rock, AR 72202, USA.
Patricia TrippUnited States Department of Agriculture-Agriculture Resaarch Service, Arkansas Children's Nutrition Center, Little Rock, AR 72202, USA.
Hoy E PittmanUnited States Department of Agriculture-Agriculture Resaarch Service, Arkansas Children's Nutrition Center, Little Rock, AR 72202, USA.
Bobby L FayUnited States Department of Agriculture-Agriculture Resaarch Service, Arkansas Children's Nutrition Center, Little Rock, AR 72202, USA.
Taylor J RossUnited States Department of Agriculture-Agriculture Resaarch Service, Arkansas Children's Nutrition Center, Little Rock, AR 72202, USA.
James D SikesUnited States Department of Agriculture-Agriculture Resaarch Service, Arkansas Children's Nutrition Center, Little Rock, AR 72202, USA.
Jessica B FlowersTechnical Services Envigo, Teklad Diets, Madison, WI 53713, USA.
Fabiana Bar-YosephElse Nutrition GH, Tel Aviv 6971070, Israel.
Laxmi YeruvaUnited States Department of Agriculture-Agriculture Resaarch Service, Arkansas Children's Nutrition Center, Little Rock, AR 72202, USA.ORCID 0000-0003-4289-9109

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A randomized neonatal piglet trial was conducted to evaluate the safety and the effects of a plant-based formula containing almonds and buckwheat as the main ingredients on growth and plasma parameters. From postnatal day (PND) 2 to 21, the piglets were fed a dairy-based milk formula (Similac Advance) or a plant-based formula (Else Nutrition) and all piglets were euthanized at day 21. No diarrhea was observed after PND 8 and all the piglets completed the trial. Body growth, kcal intake, the complete plasma count parameters and hematological parameters were within the reference range in both groups. Organ growth and development was similar between the two groups. Plasma glucose was higher in the dairy-based-fed piglets relative to the plant-based at 2 weeks of age. Liver function biomarkers levels were greater in the plasma of the plant-based compared to the dairy-based fed group. In addition, calcium levels were higher in the plant-based fed piglets at 1 week of age. Thus, the plant-based formula tested in this study was well tolerated by the piglets and supported similar growth compared to dairy-based milk formula. Therefore, the results support the safety of the tested plant-based infant formula during the neonatal period in comparison to the dairy-based formula fed group.

Indexed as

FagopyrumInfant FormulaPrunus dulcisAnimalsAnimals, NewbornMilkNutritional StatusSwineinfant formulametabolismpiglet modelplant-based

Identifiers

PMID35406111
PMCPMC9002815

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.