Evidence map›Paper›PMID 35406088›Full record

ArticleNutrients2022

Consumption of Cashew (

Ramona D'Amico, Marika Cordaro, Roberta Fusco, Alessio Filippo Peritore, Tiziana Genovese, Enrico Gugliandolo, Rosalia Crupi, Giuseppina Mandalari, Daniela Caccamo, Salvatore Cuzzocrea and 3 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 1 institution in 2 countries.

Ramona D'AmicoDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Via F. Stagno D'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0003-0389-3871
Marika CordaroDepartment of Biomedical, Dental and Morphological and Functional Imaging, University of Messina, Via Consolare Valeria, 98125 Messina, Italy.ORCID 0000-0002-3980-0043
Roberta FuscoDepartment of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.ORCID 0000-0003-0223-1403
Alessio Filippo PeritoreDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Via F. Stagno D'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0001-8545-990X
Tiziana GenoveseDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Via F. Stagno D'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0002-3335-7327
Enrico GugliandoloDepartment of Veterinary Sciences, University of Messina, 98168 Messina, Italy.ORCID 0000-0001-6840-3154
Rosalia CrupiDepartment of Veterinary Sciences, University of Messina, 98168 Messina, Italy.ORCID 0000-0002-7629-3132
Giuseppina MandalariDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Via F. Stagno D'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0001-5663-3702
Daniela CaccamoDepartment of Biomedical, Dental and Morphological and Functional Imaging, University of Messina, Via Consolare Valeria, 98125 Messina, Italy.
Salvatore CuzzocreaDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Via F. Stagno D'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0001-6131-3690
Rosanna Di PaolaDepartment of Veterinary Sciences, University of Messina, 98168 Messina, Italy.ORCID 0000-0001-6725-8581
Rosalba SiracusaDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Via F. Stagno D'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0001-7868-2505
Daniela ImpellizzeriDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Via F. Stagno D'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0001-9492-3161
University of Messina · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyperhomocysteinemia (HHcy) is a methionine metabolism problem that causes a variety of inflammatory illnesses. Oxidative stress is among the processes thought to be involved in the pathophysiology of the damage produced by HHcy. HHcy is likely to involve the dysfunction of several organs, such as the kidney, liver, or gut, which are currently poorly understood. Nuts are regarded as an important part of a balanced diet since they include protein, good fatty acids, and critical nutrients. The aim of this work was to evaluate the anti-inflammatory and antioxidant effects of cashew nuts in HHcy induced by oral methionine administration for 30 days, and to examine the possible pathways involved. In HHcy rats, cashew nuts (100 mg/kg orally, daily) were able to counteract clinical biochemical changes, oxidative and nitrosative stress, reduced antioxidant enzyme levels, lipid peroxidation, proinflammatory cytokine release, histological tissue injuries, and apoptosis in the kidney, colon, and liver, possibly by the modulation of the antioxidant nuclear factor erythroid 2-related factor 2 NRF-2 and inflammatory nuclear factor NF-kB pathways. Thus, the results suggest that the consumption of cashew nuts may be beneficial for the treatment of inflammatory conditions associated with HHcy.

Indexed as

AnacardiumHyperhomocysteinemiaAnimalsAntioxidantsInflammationMethionineNutsOxidative StressRatsAntioxidantsMethioninecashew nuthyperhomocysteinemiaNF-κBNRF-2oxidative stress

Identifiers

PMID35406088
PMCPMC9002620
OpenAlexW4223418229

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.