SynthesisNutrients2022
Gastrointestinal Symptoms in Autism Spectrum Disorder: A Systematic Review.
Synthesis in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07086157 (Effects of Low-FODMAP Diet and Probiotics on Gastrointestinal Symptoms, Behavior Problems, and Microbiota in Children With Autism Spectrum Disorder and Gastrointestinal Symptoms), which is not on this map. Cited by 85 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Low-FODMAP Diet and Probiotics on Gastrointestinal Symptoms, Behavior Problems, and Microbiota in Children With Autism Spectrum Disorder and Gastrointestinal Symptoms
Who cites it
85 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effect of nutritional supplements on gut microbiome in individuals with neurodevelopmental disorders: a systematic review and narrative synthesis.BMC nutrition · 2025Pooled it
- Recognition of the microbial metaboliteFrontiers in molecular neuroscience · 2025Pooled it
- Prevalence of autism spectrum disorder in mainland china over the past 6 years: a systematic review and meta-analysis.BMC psychiatry · 2024Pooled it
- A post hoc analysis of linaclotide in pediatric patients with functional constipation and neurodevelopmental disorders.Journal of pediatric gastroenterology and nutrition · 2026Trial
- Gastrointestinal, Behaviour and Anxiety Outcomes in Autistic Children Following an Open Label, Randomised Pilot Study of Synbiotics vs Synbiotics and Gut-Directed Hypnotherapy.Journal of autism and developmental disorders · 2026Trial
- Trial
- Impact of probiotic supplements on behavioural and gastrointestinal symptoms in children with autism spectrum disorder: A randomised controlled trial.BMJ paediatrics open · 2025Trial
- A Double-Blind Randomised Controlled Trial of Prebiotic Supplementation in Children with Autism: Effects on Parental Quality of Life, Child Behaviour, Gastrointestinal Symptoms, and the Microbiome.Journal of autism and developmental disorders · 2025Trial
- Overall Weak Association Between Gastrointestinal Symptoms and Psychological, Autism, and Demographic Variables in Autistic Children.Autism : the international journal of research and practice · 2026Article
- Constipation outcomes in children with and without autism spectrum disorder: Insights from a tertiary motility service.Journal of pediatric gastroenterology and nutrition · 2026Article
- Teaching Practitioners to Use the Bristol Stool Form Scale.Behavior analysis in practice · 2026Article
- Clinical Characteristics and Blood-Based Inflammatory Indices of Psychiatric Hospitalizations Among Children with Autism in China: A Retrospective Electronic Medical Records Study.Brain sciences · 2026Article
- [Focusing on profound autism: validity of clinical taxonomy and management of treatment-resistant symptoms].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Review
- Interaction of the Gut Microbiota and the Enteric Nervous System: Implications in Gastrointestinal Disorders Associated With Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2026Review
- Article
- Limosilactobacillus reuteri LR-99 Modulates Gut Microbiota and Core Symptoms in Children with Autism Spectrum Disorder: A Single-arm Pilot Study.Probiotics and antimicrobial proteins · 2026Article
- Autism spectrum disorder across the lifespan: Dynamic symptom trajectories and multidimensional support framework.Molecular psychiatry · 2026Review
- Mealtime behaviours, diet quality and parental stress in children with autism spectrum disorder: a cross-sectional study from Türkiye.BMJ paediatrics open · 2026Article
- Relationship Between Calcium and Gut Microbial Composition and Metabolic Pathways in Children with Autism.Metabolites · 2026Article
- Development of a Metagenomics-Guided Personalized Synbiotic Protocol for Children with Autism Spectrum Disorder: An Exploratory Case Series.Nutrients · 2026Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This systematic review aims to offer an updated understanding of the relationship between gastrointestinal symptoms (GIS) and autism spectrum disorder (ASD) in children and adolescents. The databases PsycINFO, Medline, Cinahl, and ERIC were searched using keywords, and relevant literature was hand-searched. Papers (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.