Evidence map›Paper›PMID 35406005›Full record

ArticleNutrients2022

Zinc Deficiency Interacts with Intestinal/Urogenital Parasites in the Pathway to Anemia in Preschool Children, Bengo-Angola.

Cláudia Fançony, Ânia Soares, João Lavinha, Miguel Brito

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Cláudia FançonyCentro de Investigação em Saúde de Angola (CISA), Caxito, Estação Central de Luanda, Apartado IV n °5547, Luanda 5547, Angola.
Ânia SoaresCentro de Investigação em Saúde de Angola (CISA), Caxito, Estação Central de Luanda, Apartado IV n °5547, Luanda 5547, Angola.
João LavinhaDepartamento de Genética Humana, Avenida Padre Cruz, Instituto Nacional de Saúde Dr. Ricardo Jorge, 1649-016 Lisboa, Portugal.ORCID 0000-0002-7474-6871
Miguel BritoCentro de Investigação em Saúde de Angola (CISA), Caxito, Estação Central de Luanda, Apartado IV n °5547, Luanda 5547, Angola.ORCID 0000-0001-6394-658X
Instituto Politécnico de Lisboa · PTNational Institute of Health Dr. Ricardo Jorge · PT

Funding

Calouste Gulbenkian Foundation NA
6 · The paper itself

Abstract

In host organisms with normal micronutrient status, nutritional immunity is a strongly regulated response aiming at decreasing the progression and severity of infections. Zinc deficiency may disturb this balance, impairing immune responses to infections, which may indirectly increase infection-related anemia. Since zinc deficiency may associate directly with anemia, the role of infections is often overlooked. Herein, we investigated the participation of infections (or inflammation) in the causal pathway between zinc deficiency and anemia. This transversal study, conducted in 2015 in Bengo-Angola, enrolled 852 under-3-year-old children. Logistic regression models were used to investigate interaction and mediation effects, and significance was confirmed by the Sobel test. In sum, 6.8% of children had zinc deficiency, 45.9% had anemia, and 15.6% had at least one intestinal/urogenital parasite. Furthermore, we found (1) no evidence that inflammation mediates or interacts with zinc deficiency to cause anemia, and (2) zinc deficiency interacts with infections, significantly increasing the odds of anemia (OR: 13.26,

Indexed as

AnemiaAnemia, Iron-DeficiencyIntestinal Diseases, ParasiticMalnutritionParasitesAngolaAnimalsChild, PreschoolHumansInflammationMicronutrientsNutritional StatusPrevalenceZincMicronutrientsZincanemiainfectionsinflammationzinc deficiency

Identifiers

PMID35406005
PMCPMC9002711
OpenAlexW4220963640

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.