Evidence map›Paper›PMID 35405993›Full record

ArticleNutrients2022

Diet, Fecal Microbiome, and Trimethylamine N-Oxide in a Cohort of Metabolically Healthy United States Adults.

Kristen L James, Erik R Gertz, Eduardo Cervantes, Ellen L Bonnel, Charles B Stephensen, Mary E Kable, Brian J Bennett

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Abnormal "Frontiers in cardiovascular medicine · 2026
    Trial
  3. Trial
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Benefits of Taurisolo in Diabetic Patients with Peripheral Artery Disease.Journal of cardiovascular development and disease · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kristen L JamesDepartment of Nutrition, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA.ORCID 0000-0002-3704-3560
Erik R GertzUSDA-ARS Western Human Nutrition Research Center, 430 West Health Sciences Drive, Davis, CA 95616, USA.
Eduardo CervantesDepartment of Nutrition, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA.ORCID 0000-0002-5480-5619
Ellen L BonnelDepartment of Nutrition, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA.
Charles B StephensenDepartment of Nutrition, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA.
Mary E KableDepartment of Nutrition, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA.ORCID 0000-0002-5485-6539
Brian J BennettDepartment of Nutrition, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA.
West Health · USUniversity of California, Davis · US

Funding

Biological Mechanisms through which TMAO Promotes AtherosclerosisR01HL148110 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ALLAYEE, HOOMAN, SHIH, DIANA MOUHAN · 2020 to 2023
$2.5M
NHLBI NIH HHS R01 HL148110NIH HHS RO1HL148110The Beef Checkoff 58-2032-8-035United States Department of Agriculture 2032-51530-025-00D
6 · The paper itself

Abstract

TMAO is elevated in individuals with cardiometabolic diseases, but it is unknown whether the metabolite is a biomarker of concern in healthy individuals. We conducted a cross-sectional study in metabolically healthy adults aged 18-66 years with BMI 18-44 kg/m

Indexed as

MethylaminesMicrobiotaAnimalsBiomarkersCross-Sectional StudiesDietHumansProspective StudiesUnited StatesBiomarkersMethylaminestrimethyloxamineASA24endoPATendothelial functioninflammationmicrobiomeTMAOTNF-alphatrimethylamine n-oxide

Identifiers

PMID35405993
PMCPMC9003533
OpenAlexW4221079216

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.