ArticleNutrients2022
Vitamin D Deficiency and Its Association with Iron Deficiency in African Children.
Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Genetic polymorphisms influencing deferasirox pharmacokinetics, efficacy, and adverse drug reactions: a systematic review and meta-analysis.Frontiers in pharmacology · 2023Pooled it
- Cohort profile: the Entebbe Mother and Baby Study (EMaBS).BMJ open · 2026Trial
- Comparative analysis of two analytical methodologies for deriving dietary patterns associated with vitamin D insufficiency and anemia among expectant mothers.International journal of medical sciences · 2026Article
- Article
- Association of the Transmembrane Protease Serine 6 rs855791 Variant and Nongenetic Factors With Iron Deficiency Among Female Medical Students in Yogyakarta: Protocol for a Case-Control Study.JMIR research protocols · 2025Article
- Factors associated with the serum 25-hydroxyvitamin D levels in adults.BMC nutrition · 2025Article
- Prevention of chronic disease using vitamins-a case study of the vitamin D and cardiovascular disease hypothesis using evidence from randomised controlled and prospective cohort studies.European journal of nutrition · 2025Article
- Minerals and Human Health: From Deficiency to Toxicity.Nutrients · 2025Review
- The Interplay Between Vitamin D Deficiency, Iron Status, and Anemia Risk in Moroccan Women of Reproductive Age: A Cross-Sectional Analysis.Epidemiologia (Basel, Switzerland) · 2024Article
- Multifaceted determinants of micronutrient status in early childhood in Iran : National food and nutrition surveillance.European journal of nutrition · 2024Article
- Hormones in malaria infection: influence on disease severity, host physiology, and therapeutic opportunities.Bioscience reports · 2024Review
- Increased Cadmium Load, Vitamin D Deficiency, and Elevated FGF23 Levels as Pathophysiological Factors Potentially Linked to the Onset of Acute Lymphoblastic Leukemia: A Review.Journal of personalized medicine · 2024Review
- Review
- Calcium, Phosphate, and Vitamin D in Children and Adolescents with Chronic Diseases: A Cross-Sectional Study.Nutrients · 2024Article
- Article
- Association Between Serum 25-Hydroxyvitamin D Level and Risk of Anemia: An Observational and Mendelian Randomization Study.International journal of general medicine · 2024Article
- Review
- Maternal prenatal, with or without postpartum, vitamin D3 supplementation does not improve maternal iron status at delivery or infant iron status at 6 months of age: secondary analysis of a randomised controlled trial.BMJ nutrition, prevention & health · 2023Article
- Interplay of Vitamin D, Unfolded Protein Response, and Iron Metabolism in Neuroblastoma Cells: A Therapeutic Approach in Neurodegenerative Conditions.International journal of molecular sciences · 2023Article
- A Cross-Sectional Study of the Associations between Biomarkers of Vitamin D, Iron Status, and Hemoglobin in South African Women of Reproductive Age: the Healthy Life Trajectories Initiative, South Africa.Current developments in nutrition · 2023Article
Corrections and comments
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Authors and funding
21 authors at 10 institutions in 7 countries.
Funding
Abstract
Vitamin D regulates the master iron hormone hepcidin, and iron in turn alters vitamin D metabolism. Although vitamin D and iron deficiency are highly prevalent globally, little is known about their interactions in Africa. To evaluate associations between vitamin D and iron status we measured markers of iron status, inflammation, malaria parasitemia, and 25-hydroxyvitamin D (25(OH)D) concentrations in 4509 children aged 0.3 months to 8 years living in Kenya, Uganda, Burkina Faso, The Gambia, and South Africa. Prevalence of iron deficiency was 35.1%, and prevalence of vitamin D deficiency was 0.6% and 7.8% as defined by 25(OH)D concentrations of <30 nmol/L and <50 nmol/L, respectively. Children with 25(OH)D concentrations of <50 nmol/L had a 98% increased risk of iron deficiency (OR 1.98 [95% CI 1.52, 2.58]) compared to those with 25(OH)D concentrations >75 nmol/L. 25(OH)D concentrations variably influenced individual markers of iron status. Inflammation interacted with 25(OH)D concentrations to predict ferritin levels. The link between vitamin D and iron status should be considered in strategies to manage these nutrient deficiencies in African children.
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Registered trials
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